Literature DB >> 26808693

Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.

Steven J Ackerman1,2, Gye Young Park2, John W Christman3, Sharmilee Nyenhuis2, Evgeny Berdyshev4, Viswanathan Natarajan2,5.   

Abstract

Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following subsegmental bronchoprovocation with allergen in subjects with allergic asthma. Polyunsaturated molecular species of LPA (C22:5 and C22:6) are selectively synthesized in the airways of asthma subjects following allergen challenge and in mouse models of allergic airway inflammation, having been identified and quantified by LC/MS/MS lipidomics. This review discusses current knowledge of LPA production in asthmatic lung and the potential utility of polyunsaturated LPA molecular species as novel biomarkers in bronchoalveolar lavage fluid and exhaled breath condensate of asthma subjects.

Entities:  

Keywords:  LPA receptors; airway epithelium; allergic airway inflammation; asthma biomarkers; autotaxin; bronchoalveolar lavage fluid; eosinophils; exhaled breath condensate; lysophosphatidic acid (LPA); macrophages

Mesh：

Substances：

Year:  2016        PMID： 26808693      PMCID： PMC4881841          DOI： 10.2217/bmm.15.93

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  52 in total

1.  Allergic to autotaxin. A new role for lysophospholipase d and lysophosphatidic Acid in asthma?

Authors:  Steve N Georas
Journal:  Am J Respir Crit Care Med       Date:  2013-10-15       Impact factor: 21.405

Review 2.  Year in review 2014: asthma.

Authors:  Kathleen M Deakins
Journal:  Respir Care       Date:  2015-04-14       Impact factor: 2.258

Review 3.  Pathobiology of severe asthma.

Authors:  Humberto E Trejo Bittar; Samuel A Yousem; Sally E Wenzel
Journal:  Annu Rev Pathol       Date:  2014-11-24       Impact factor: 23.472

Review 4.  Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.

Authors:  Yutong Zhao; Viswanathan Natarajan
Journal:  Biochim Biophys Acta       Date:  2012-07-15

Review 5.  Novel biomarkers for asthma stratification and personalized therapy.

Authors:  Grzegorz Bartminski; Matthew Crossley; Victor Turcanu
Journal:  Expert Rev Mol Diagn       Date:  2014-12-05       Impact factor: 5.225

6.  Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.

Authors:  Knut Kotarsky; Ake Boketoft; Jesper Bristulf; Niclas E Nilsson; Ake Norberg; Stefan Hansson; Christer Owman; Rannar Sillard; L M Fredrik Leeb-Lundberg; Björn Olde
Journal:  J Pharmacol Exp Ther       Date:  2006-05-01       Impact factor: 4.030

7.  Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.

Authors:  Donghong He; Viswanathan Natarajan; Randi Stern; Irina A Gorshkova; Julian Solway; Ernst Wm Spannhake; Yutong Zhao
Journal:  Biochem J       Date:  2008-05-15       Impact factor: 3.857

8.  Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.

Authors:  Nikos Oikonomou; Marios-Angelos Mouratis; Argyris Tzouvelekis; Eleanna Kaffe; Christos Valavanis; George Vilaras; Andreas Karameris; Glenn D Prestwich; Demosthenes Bouros; Vassilis Aidinis
Journal:  Am J Respir Cell Mol Biol       Date:  2012-06-28       Impact factor: 6.914

9.  Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways.

Authors:  Hongkuan Fan; Basilia Zingarelli; Vashaunta Harris; George E Tempel; Perry V Halushka; James A Cook
Journal:  Mol Med       Date:  2008 Jul-Aug       Impact factor: 6.354

10.  Regulation of T cell motility in vitro and in vivo by LPA and LPA2.

Authors:  Sara A Knowlden; Tara Capece; Milan Popovic; Timothy J Chapman; Fariba Rezaee; Minsoo Kim; Steve N Georas
Journal:  PLoS One       Date:  2014-07-08       Impact factor: 3.240
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  21 in total

1.  Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry.

Authors:  Maria P Kraemer; Suchismita Halder; Susan S Smyth; Andrew J Morris
Journal:  Methods Mol Biol       Date:  2018

Review 2.  The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma.

Authors:  Seung-Jae Kim; Hyung-Geun Moon; Gye Young Park
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2020-01-29       Impact factor: 4.698

3.  Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.

Authors:  Xinping Liu; Sung Ho Moon; Christopher M Jenkins; Harold F Sims; Richard W Gross
Journal:  Cell Chem Biol       Date:  2016-09-15       Impact factor: 8.116

4.  Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid.

Authors:  Maria P Kraemer; Guogen Mao; Courtney Hammill; Baoxiang Yan; Yu Li; Fredrick Onono; Susan S Smyth; Andrew J Morris
Journal:  J Lipid Res       Date:  2019-09-04       Impact factor: 5.922

5.  Lysophospholipids in Lung Inflammatory Diseases.

Authors:  Jing Zhao; Yutong Zhao
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

6.  Huanglong Antitussive Granule Relieves Acute Asthma Through Regulating Pulmonary Lipid Homeostasis.

Authors:  Hua Yan; Guiying Qian; Rui Yang; Zichen Luo; Xianzheng Wang; Tong Xie; Xia Zhao; Jinjun Shan
Journal:  Front Pharmacol       Date:  2021-04-23       Impact factor: 5.810

Review 7.  Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids.

Authors:  Eva Knuplez; Eva Maria Sturm; Gunther Marsche
Journal:  Int J Mol Sci       Date:  2021-04-21       Impact factor: 5.923

8.  Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis - a potential biomarker role for LysoPC.

Authors:  Barbara Rindlisbacher; Cornelia Schmid; Thomas Geiser; Cédric Bovet; Manuela Funke-Chambour
Journal:  Respir Res       Date:  2018-01-10

9.  The incidence and risk of osteoporosis in patients with anxiety disorder: A Population-based retrospective cohort study.

Authors:  Chen Hong-Jhe; Kuo Chin-Yuan; Tu Ming-Shium; Wang Fu-Wei; Chen Ru-Yih; Hsueh Kuang-Chieh; Pan Hsiang-Ju; Chou Ming-Yueh; Chen Pan-Ming; Pan Chih-Chuan
Journal:  Medicine (Baltimore)       Date:  2016-09       Impact factor: 1.889

Review 10.  Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

Authors:  Matthew G K Benesch; Iain T K MacIntyre; Todd P W McMullen; David N Brindley
Journal:  Cancers (Basel)       Date:  2018-03-15       Impact factor: 6.639
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