Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma.

Literature DB >> 32004685

The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma.

Seung-Jae Kim¹, Hyung-Geun Moon¹, Gye Young Park².

Abstract

Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a key role in establishing allergic airway inflammation and aggravation of allergic asthma. Published by Elsevier B.V.

Entities: CellLine Chemical Disease Gene Species

Keywords: Airway inflammation; Asthma; Autotaxin; Lysophosphatidic acid; Lysophosphatidic acid receptors

Mesh：

Substances：

Year: 2020 PMID： 32004685 PMCID： PMC7068735 DOI： 10.1016/j.bbalip.2020.158641

Source DB: PubMed Journal: Biochim Biophys Acta Mol Cell Biol Lipids ISSN： 1388-1981 Impact factor: 4.698

131 in total

1. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells.

Authors: D R Cerutis; M Nogami; J L Anderson; J D Churchill; D J Romberger; S I Rennard; M L Toews
Journal: Am J Physiol Date: 1997-07

2. Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α.

Authors: Linmu Chen; Jun Zhang; Xi Yang; Yan Liu; Xiao Deng; Chao Yu
Journal: Atherosclerosis Date: 2019-09-11 Impact factor: 5.162

3. Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.

Authors: Shannon K Oda; Pamela Strauch; Yuko Fujiwara; Amin Al-Shami; Tamas Oravecz; Gabor Tigyi; Roberta Pelanda; Raul M Torres
Journal: Cancer Immunol Res Date: 2013-10 Impact factor: 11.151

Review 4. Tissue-Resident Macrophage Ontogeny and Homeostasis.

Authors: Florent Ginhoux; Martin Guilliams
Journal: Immunity Date: 2016-03-15 Impact factor: 31.745

5. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

Authors: Youdong Pan; Tian Tian; Chang Ook Park; Serena Y Lofftus; Shenglin Mei; Xing Liu; Chi Luo; John T O'Malley; Ahmed Gehad; Jessica E Teague; Sherrie J Divito; Robert Fuhlbrigge; Pere Puigserver; James G Krueger; Gökhan S Hotamisligil; Rachael A Clark; Thomas S Kupper
Journal: Nature Date: 2017-02-20 Impact factor: 49.962

6. Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge.

Authors: S N Georas; E Berdyshev; W Hubbard; I A Gorshkova; P V Usatyuk; B Saatian; A C Myers; M A Williams; H Q Xiao; M Liu; V Natarajan
Journal: Clin Exp Allergy Date: 2007-03 Impact factor: 5.018

7. Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.

Authors: Yutong Zhao; Donghong He; Jing Zhao; Lixin Wang; Alan R Leff; Ernst Wm Spannhake; Steve Georas; Viswanathan Natarajan
Journal: J Biol Chem Date: 2007-02-06 Impact factor: 5.157

8. Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.

Authors: Nikos Oikonomou; Marios-Angelos Mouratis; Argyris Tzouvelekis; Eleanna Kaffe; Christos Valavanis; George Vilaras; Andreas Karameris; Glenn D Prestwich; Demosthenes Bouros; Vassilis Aidinis
Journal: Am J Respir Cell Mol Biol Date: 2012-06-28 Impact factor: 6.914

9. Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization.

Authors: Yixin Jin; Eirunn Knudsen; Ling Wang; Azzam A Maghazachi
Journal: Eur J Immunol Date: 2003-08 Impact factor: 5.532

10. Lysophosphatidic acid induces neointima formation through PPARgamma activation.

Authors: Chunxiang Zhang; Daniel L Baker; Satoshi Yasuda; Natalia Makarova; Louisa Balazs; Leonard R Johnson; Gopal K Marathe; Thomas M McIntyre; Yong Xu; Glenn D Prestwich; Hoe-Sup Byun; Robert Bittman; Gabor Tigyi
Journal: J Exp Med Date: 2004-03-08 Impact factor: 14.307

8 in total

1. Lysophospholipids in Lung Inflammatory Diseases.

Authors: Jing Zhao; Yutong Zhao
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

2. Novel Pyridazines as Autotaxin Inhibitors for Treating Inflammatory Airway or Fibrotic Diseases.

Authors: Ram W Sabnis
Journal: ACS Med Chem Lett Date: 2021-03-16 Impact factor: 4.345

Review 3. Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids.

Authors: Eva Knuplez; Eva Maria Sturm; Gunther Marsche
Journal: Int J Mol Sci Date: 2021-04-21 Impact factor: 5.923

8. A Novel Therapeutic Reagent, KA-1002 for Alleviating Lysophosphatidic Acid-Mediated Inflammation Related Gene Expression in Swine Macrophages.

Authors: Hyeon-Jeong Hwang; Tamina Park; Miok Kim; Hee-Su Shin; Wooyeon Hwang; Yong Ki Min; Suk-Gil Song; Daeui Park; Chang Hoon Lee
Journal: Animals (Basel) Date: 2020-03-23 Impact factor: 2.752