Zahra Bahaeddin1, Asal Yans2, Fariba Khodagholi2,3, Homa Hajimehdipoor1, Shamim Sahranavard1. 1. a Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy , School of Traditional Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 2. b Neuroscience Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran. 3. c NeuroBiology Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Abstract
OBJECTIVES: Corylus avellana L. (hazelnut) is known to be a delicious and nutritious food. This study was carried out to evaluate the use of hazelnut as a therapy for memory impairment because in Iranian traditional medicine, it is recommended for those suffering from a particular type of dementia, with symptoms of Alzheimer's disease. METHODS: In this study, rats were fed with hazelnut kernel [(without skin) 800 mg/kg/day] during 1 week before stereotaxic surgery to 24 hours before behavioral testing (in general, for 16 consecutive days) and the effect of hazelnut eating on memory, anxiety, neuroinflammation and apoptosis was assessed in the amyloid beta-injected rat. RESULTS: The results of this study showed that feeding with hazelnut improved memory, (which was examined by using Y-maze test and shuttle box apparatus), and reduced anxiety-related behavior, that was evaluated using elevated plus maze. Also, western blotting analysis of cyclooxygenase-2, interleukin-1β, tumor necrosis factor-α, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, and caspase-3 showed that hazelnut has an ameliorating effect on the neuroinflammation and apoptosis caused by Aβ. DISCUSSION: These findings suggest that hazelnut, as a dietary supplement, improves healthy aging and could be a beneficial diet for the treatment of AD.
OBJECTIVES:Corylus avellana L. (hazelnut) is known to be a delicious and nutritious food. This study was carried out to evaluate the use of hazelnut as a therapy for memory impairment because in Iranian traditional medicine, it is recommended for those suffering from a particular type of dementia, with symptoms of Alzheimer's disease. METHODS: In this study, rats were fed with hazelnut kernel [(without skin) 800 mg/kg/day] during 1 week before stereotaxic surgery to 24 hours before behavioral testing (in general, for 16 consecutive days) and the effect of hazelnut eating on memory, anxiety, neuroinflammation and apoptosis was assessed in the amyloid beta-injected rat. RESULTS: The results of this study showed that feeding with hazelnut improved memory, (which was examined by using Y-maze test and shuttle box apparatus), and reduced anxiety-related behavior, that was evaluated using elevated plus maze. Also, western blotting analysis of cyclooxygenase-2, interleukin-1β, tumor necrosis factor-α, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, and caspase-3 showed that hazelnut has an ameliorating effect on the neuroinflammation and apoptosis caused by Aβ. DISCUSSION: These findings suggest that hazelnut, as a dietary supplement, improves healthy aging and could be a beneficial diet for the treatment of AD.
Authors: Roberta Cristina de França Silva; Mikaelle Albuquerque de Souza; Jaielison Yandro Pereira da Silva; Carolina da Silva Ponciano; Vanessa Bordin Viera; Camila Carolina de Menezes Santos Bertozzo; Gerlane Coelho Guerra; Daline Fernandes de Souza Araújo; Marta Maria da Conceição; Celina de Castro Querino Dias; Maria Elieidy Oliveira; Juliana Kessia Barbosa Soares Journal: PLoS One Date: 2021-03-17 Impact factor: 3.240