Literature DB >> 26808610

PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis.

Yinwei Zhang1, Liangwei Li1, Yuan Liu1, Zhi-Ren Liu1.   

Abstract

Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
© 2016 by the Wound Healing Society.

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Year:  2016        PMID： 26808610      PMCID： PMC5873584          DOI： 10.1111/wrr.12411

Source DB:  PubMed          Journal:  Wound Repair Regen        ISSN： 1067-1927            Impact factor:   3.617


  42 in total

Review 1.  Cutaneous wound healing.

Authors:  A J Singer; R A Clark
Journal:  N Engl J Med       Date:  1999-09-02       Impact factor: 91.245

2.  Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

Authors:  Xueliang Gao; Haizhen Wang; Jenny J Yang; Xiaowei Liu; Zhi-Ren Liu
Journal:  Mol Cell       Date:  2012-02-02       Impact factor: 17.970

Review 3.  Wound healing: an overview.

Authors:  George Broughton; Jeffrey E Janis; Christopher E Attinger
Journal:  Plast Reconstr Surg       Date:  2006-06       Impact factor: 4.730

4.  Control of secondary granule release in neutrophils by Ral GTPase.

Authors:  Celia X-J Chen; Ileana Soto; Ya-Lan Guo; Yuan Liu
Journal:  J Biol Chem       Date:  2011-01-31       Impact factor: 5.157

5.  Pyruvate kinase activity and isozyme composition in normal fibrous tissue and fibroblastic proliferations.

Authors:  J R Elbers; J A van Unnik; G Rijksen; B A van Oirschot; P J Roholl; J Oosting; G E Staal
Journal:  Cancer       Date:  1991-05-15       Impact factor: 6.860

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Authors:  Joachim Schneider; Kathleen Neu; Helmut Grimm; Hans-Georg Velcovsky; Gunter Weisse; Erich Eigenbrodt
Journal:  Anticancer Res       Date:  2002 Jan-Feb       Impact factor: 2.480

Review 7.  Tumor markers in detection of lung cancer.

Authors:  Joachim Schneider
Journal:  Adv Clin Chem       Date:  2006       Impact factor: 5.394

8.  Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors.

Authors:  C Gardi; E Cavarra; P Calzoni; P Marcolongo; M de Santi; P A Martorana; G Lungarella
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

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