Literature DB >> 25070887

Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.

Liangwei Li1, Yinwei Zhang1, Jingjuan Qiao2, Jenny J Yang2, Zhi-Ren Liu3.   

Abstract

It is long known that pyruvate kinase isoform M2 (PKM2) is released into the circulation of cancer patients. The PKM2 levels in patients have been suggested as a diagnostic marker for many types of cancers. However, it is not known how PKM2 is released in the blood, and whether the circulating PKM2 has any physiological function(s) in tumor progression. In this report, we demonstrate that PKM2 in the blood facilitates tumor growth by promoting tumor angiogenesis. Our experiments show that PKM2 promotes tumor angiogenesis by increasing endothelial cell proliferation, migration, and cell-ECM adhesion. Only the dimeric PKM2 possess the activity in promoting tumor angiogenesis, which is consistent with the observations that PKM2 in circulation of cancer patients is a dimer form.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Angiogenesis; Cell Adhesion; Cell Migration; Endothelial Cell; Glycolysis; Pyruvate Kinase

Mesh：

Substances：

Year:  2014        PMID： 25070887      PMCID： PMC4162182          DOI： 10.1074/jbc.M114.576934

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  23 in total

1.  Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Authors:  Jill D Dombrauckas; Bernard D Santarsiero; Andrew D Mesecar
Journal:  Biochemistry       Date:  2005-07-12       Impact factor: 3.162

2.  Tumor type M2 pyruvate kinase (TuM2-PK) as a novel plasma tumor marker in melanoma.

Authors:  Selma Ugurel; Nellie Bell; Antje Sucker; Anette Zimpfer; Werner Rittgen; Dirk Schadendorf
Journal:  Int J Cancer       Date:  2005-12-10       Impact factor: 7.396

3.  Pyruvate kinase activity and isozyme composition in normal fibrous tissue and fibroblastic proliferations.

Authors:  J R Elbers; J A van Unnik; G Rijksen; B A van Oirschot; P J Roholl; J Oosting; G E Staal
Journal:  Cancer       Date:  1991-05-15       Impact factor: 6.860

4.  Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

Authors:  H J Hacker; P Steinberg; P Bannasch
Journal:  Carcinogenesis       Date:  1998-01       Impact factor: 4.944

5.  Quantitative detection of tumor M2-PK in serum and plasma.

Authors:  F Hugo; G Fischer; E Eigenbrodt
Journal:  Anticancer Res       Date:  1999 Jul-Aug       Impact factor: 2.480

Review 6.  Tumor markers in detection of lung cancer.

Authors:  Joachim Schneider
Journal:  Adv Clin Chem       Date:  2006       Impact factor: 5.394

7.  M2-PK as a novel marker in ovarian cancer. A prospective cohort study.

Authors:  A S Ahmed; T Dew; F G Lawton; A J Papadopoulos; O Devaja; K S Raju; R A Sherwood
Journal:  Eur J Gynaecol Oncol       Date:  2007       Impact factor: 0.196

8.  Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.

Authors:  Hai-Feng Duan; Xian-Wen Hu; Jin-Long Chen; Li-Hua Gao; Yong-Yi Xi; Ying Lu; Jin-Feng Li; Su-Rong Zhao; Jun-Jie Xu; Hui-Peng Chen; Wei Chen; Chu-Tse Wu
Journal:  J Natl Cancer Inst       Date:  2007-10-09       Impact factor: 13.506

9.  The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma.

Authors:  R Weinberger; B Appel; A Stein; Y Metz; A Neheman; M Barak
Journal:  Eur J Cancer Care (Engl)       Date:  2007-07       Impact factor: 2.520

Review 10.  Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy.

Authors:  Harsha R Hathurusinghe; Kolitha S Goonetilleke; Ajith K Siriwardena
Journal:  Ann Surg Oncol       Date:  2007-06-30       Impact factor: 5.344
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  33 in total

Review 1.  Pyruvate kinase M2: A simple molecule with complex functions.

Authors:  Mohammed Alquraishi; Dexter L Puckett; Dina S Alani; Amal S Humidat; Victoria D Frankel; Dallas R Donohoe; Jay Whelan; Ahmed Bettaieb
Journal:  Free Radic Biol Med       Date:  2019-08-08       Impact factor: 7.376

2.  Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.

Authors:  Ming-Chuan Hsu; Wen-Chun Hung; Hirohito Yamaguchi; Seung-Oe Lim; Hsin-Wei Liao; Chia-Hua Tsai; Mien-Chie Hung
Journal:  Am J Cancer Res       Date:  2016-02-15       Impact factor: 6.166

Review 3.  Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.

Authors:  Shutao Zheng; Qing Liu; Tao Liu; Xiaomei Lu
Journal:  J Physiol Biochem       Date:  2021-04-09       Impact factor: 4.158

Review 4.  A critical review of the role of M2PYK in the Warburg effect.

Authors:  Robert A Harris; Aron W Fenton
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2019-01-29       Impact factor: 10.680

5.  MicroRNA 675 cooperates PKM2 to aggravate progression of human liver cancer stem cells induced from embryonic stem cells.

Authors:  Yuxin Yang; Qiuyu Meng; Chen Wang; Xiaonan Li; Yanan Lu; Xiaoru Xin; Qidi Zheng; Dongdong Lu
Journal:  J Mol Med (Berl)       Date:  2018-08-23       Impact factor: 4.599

6.  Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.

Authors:  Yongmei Li; Hao Zhuang; Xinran Zhang; Yuan Li; Yun Liu; Xianfu Yi; Guoxuan Qin; Wen Wei; Ruibing Chen
Journal:  Mol Cell Proteomics       Date:  2018-01-25       Impact factor: 5.911

7.  Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer.

Authors:  Yang Lin; Fangfang Liu; Yu Fan; Xiaolong Qian; Ronggang Lang; Feng Gu; Jun Gu; Li Fu
Journal:  Int J Clin Exp Pathol       Date:  2015-07-01

8.  PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis.

Authors:  Yinwei Zhang; Liangwei Li; Yuan Liu; Zhi-Ren Liu
Journal:  Wound Repair Regen       Date:  2016-03-10       Impact factor: 3.617

9.  Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.

Authors:  Dongdong Chen; Ling Wei; Zhi-Ren Liu; Jenny J Yang; Xiaohuan Gu; Zheng Z Wei; Li-Ping Liu; Shan Ping Yu
Journal:  Neurotherapeutics       Date:  2018-07       Impact factor: 7.620

10.  Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis.

Authors:  Idil Esen; William F Jiemy; Yannick van Sleen; Johan Bijzet; Daniel M de Jong; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Annemieke M H Boots; Elisabeth Brouwer
Journal:  Rheumatology (Oxford)       Date:  2022-07-06       Impact factor: 7.046
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