Literature DB >> 26808052

Erectile dysfunction after radical prostatectomy: prevalence, medical treatments, and psychosocial interventions.

Jessica C Emanu1, Isabelle K Avildsen, Christian J Nelson.   

Abstract

PURPOSE OF REVIEW: This review will discuss erectile dysfunction in prostate cancer patients following radical prostatectomy . It will focus on the prevalence and current treatments for erectile dysfunction as well as the emotional impact of erectile dysfunction and the current psychosocial interventions designed to help patients cope with this side effect. RECENT
FINDINGS: Although there is a large discrepancy in prevalence rates of erectile dysfunction after radical prostatectomy, several recent studies have cited rates as high as 85%. The concept of 'penile rehabilitation' is now the standard of practice to treat erectile dysfunction following radical prostatectomy. However, many men avoid seeking help or utilizing erectile dysfunction treatments. This avoidance is related to the shame, frustration, and distress many men with erectile dysfunction and their partners experience. Recent psychosocial interventions have been developed to facilitate the use of treatments and help men cope with erectile dysfunction. These interventions have shown initial promise, however, continued intervention development is needed to reduce distress and improve long-term erectile function outcomes.
SUMMARY: Erectile dysfunction is a significant problem following prostate cancer surgery. Although there are effective medical treatments, the development of psychosocial interventions should continue to evolve to maximize the assistance we can give to men and their partners.

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Year:  2016        PMID: 26808052      PMCID: PMC5005072          DOI: 10.1097/SPC.0000000000000195

Source DB:  PubMed          Journal:  Curr Opin Support Palliat Care        ISSN: 1751-4258            Impact factor:   2.302


  49 in total

1.  Long-term follow-up of patients receiving injection therapy for erectile dysfunction.

Authors:  C P Sundaram; W Thomas; L E Pryor; A A Sidi; K Billups; J L Pryor
Journal:  Urology       Date:  1997-06       Impact factor: 2.649

2.  Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial.

Authors:  F Montorsi; G Guazzoni; L F Strambi; L F Da Pozzo; L Nava; L Barbieri; P Rigatti; G Pizzini; A Miani
Journal:  J Urol       Date:  1997-10       Impact factor: 7.450

3.  Quality of life, behavioral problems, and marital adjustment in the first year after radical prostatectomy.

Authors:  Rodrigo Fernando Pereira; Yasmin Spaolonzi Daibs; Marcos Tobias-Machado; Antonio Carlos Lima Pompeo
Journal:  Clin Genitourin Cancer       Date:  2011-07-13       Impact factor: 2.872

4.  Impotence following radical prostatectomy: insight into etiology and prevention.

Authors:  P C Walsh; P J Donker
Journal:  J Urol       Date:  1982-09       Impact factor: 7.450

5.  Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial.

Authors:  Eva Johansson; Gunnar Steineck; Lars Holmberg; Jan-Erik Johansson; Tommy Nyberg; Mirja Ruutu; Anna Bill-Axelson
Journal:  Lancet Oncol       Date:  2011-08-05       Impact factor: 41.316

6.  The prevalence of bother, acceptance, and need for help in men with erectile dysfunction.

Authors:  B J de Boer; M L Bots; A A B Lycklama A Nijeholt; J P C Moors; Th J M Verheij
Journal:  J Sex Med       Date:  2005-05       Impact factor: 3.802

7.  A population study of the association between sexual function, sexual satisfaction and depressive symptoms in men.

Authors:  Alfredo Nicolosi; Edson D Moreira; Marco Villa; Dale B Glasser
Journal:  J Affect Disord       Date:  2004-10-15       Impact factor: 4.839

8.  Increased incidence of depressive symptoms in men with erectile dysfunction.

Authors:  R Shabsigh; L T Klein; S Seidman; S A Kaplan; B J Lehrhoff; J S Ritter
Journal:  Urology       Date:  1998-11       Impact factor: 2.649

9.  Defining sexual outcomes after treatment for localized prostate carcinoma.

Authors:  Leslie R Schover; Rachel T Fouladi; Carla L Warneke; Leah Neese; Eric A Klein; Craig Zippe; Patrick A Kupelian
Journal:  Cancer       Date:  2002-10-15       Impact factor: 6.860

10.  A randomised, wait-list controlled trial: evaluation of a cognitive-behavioural group intervention on psycho-sexual adjustment for men with localised prostate cancer.

Authors:  Heather M Siddons; Addie C Wootten; Anthony J Costello
Journal:  Psychooncology       Date:  2013-04-10       Impact factor: 3.894

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  17 in total

1.  Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus.

Authors:  Ryan Dobbs; Elizabeth Kalmanek; Shawn Choe; Daniel A Harrington; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  Exp Neurol       Date:  2018-11-02       Impact factor: 5.330

2.  Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction.

Authors:  Shawn Choe; Christopher W Bond; Daniel A Harrington; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  Nanomedicine       Date:  2016-09-06       Impact factor: 5.307

Review 3.  Indications and characteristics of penile traction and vacuum erection devices.

Authors:  Abida Sultana; Peter Grice; Josip Vukina; Ian Pearce; Vaibhav Modgil
Journal:  Nat Rev Urol       Date:  2021-11-11       Impact factor: 14.432

4.  Sonic Hedgehog Signaling in Primary Culture of Human Corpora Cavernosal Tissue From Prostatectomy, Diabetic, and Peyronie's Patients.

Authors:  Sarah Martin; Jiangping Deng; Timothy Searl; Samuel Ohlander; Daniel A Harrington; Samuel I Stupp; Danuta Dynda; Kevin T McVary; Carol A Podlasek
Journal:  J Sex Med       Date:  2022-06-23       Impact factor: 3.937

5.  Pathway Enrichment Analysis of Microarray Data Fom Human Penis of Diabetic and Peyronie's Patients, in Comparison With Diabetic Rat Erectile Dysfunction Models.

Authors:  Tim Searl; Samuel Ohlander; Kevin T McVary; Carol A Podlasek
Journal:  J Sex Med       Date:  2021-11-25       Impact factor: 3.937

6.  Peptide amphiphile delivery of sonic hedgehog protein promotes neurite formation in penile projecting neurons.

Authors:  Ryan Dobbs; Shawn Choe; Elizabeth Kalmanek; Daniel A Harrington; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  Nanomedicine       Date:  2018-07-04       Impact factor: 5.307

7.  Caspase Signaling in ED Patients and Animal Models.

Authors:  Sarah Martin; Daniel A Harrington; Samuel Ohlander; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  J Sex Med       Date:  2021-03-09       Impact factor: 3.802

8.  Sexual dysfunction damages: A legal database review.

Authors:  Erin Jesse; Wade Muncey; Daniel Harris; Kimberly Tay; Tyler Kim; Danly Omil-Lima; Ilaha Isali; Aram Loeb; Nannan Thirumavalavan
Journal:  Can Urol Assoc J       Date:  2022-05       Impact factor: 2.052

9.  Pelvic and hypogastric nerves are injured in a rat prostatectomy model, contributing to development of stress urinary incontinence.

Authors:  Marah Hehemann; Shawn Choe; Elizabeth Kalmanek; Daniel Harrington; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  Sci Rep       Date:  2018-11-06       Impact factor: 4.379

10.  Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction.

Authors:  Sarah Martin; Daniel A Harrington; Samuel Ohlander; Samuel I Stupp; Kevin T McVary; Carol A Podlasek
Journal:  Nanomedicine       Date:  2021-07-24       Impact factor: 6.096

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