Lisa Toto1, Enrico Borrelli, Luca Di Antonio, Paolo Carpineto, Rodolfo Mastropasqua. 1. *Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy; and †Ophthalmology Unit, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy.
Abstract
PURPOSE: To investigate alteration in superficial and deep retinal vascular densities and choroidal thickness, in patients affected by early and intermediate age-related macular degeneration (AMD). METHODS: All patients had undergone optical coherence tomography angiography (OCTA). All eyes were grouped into two stages: "early AMD" and "intermediate AMD." Outcome measures were superficial vessel density, deep vessel density, and choroidal thickness. A control group of healthy subjects was selected for the statistical comparisons. RESULTS: A total of 37 eyes of 37 dry AMD patients were enrolled for the study. Fourteen of 37 eyes were classified as having early AMD, the remaining 23 of 37 eyes were classified as being affected by intermediate AMD. Superficial and deep vessel densities were 39.21% ± 10.67% and 43.84% ± 11.57%, respectively, in the control group and 28.30% ± 10.73% and 36.41% ± 12.30%, respectively, in AMD patients (P = 0.001 and P = 0.017, respectively). Choroidal thickness was significantly reduced in AMD patients. CONCLUSION: In the last years, several studies have reported vascular factors playing an important role in AMD pathogenesis. We demonstrated that both superficial and deep retinal plexuses are altered among patients affected by AMD. Interestingly, this alteration starts immediately at the intermediate AMD stage and also the choroidal thickness reduction.
PURPOSE: To investigate alteration in superficial and deep retinal vascular densities and choroidal thickness, in patients affected by early and intermediate age-related macular degeneration (AMD). METHODS: All patients had undergone optical coherence tomography angiography (OCTA). All eyes were grouped into two stages: "early AMD" and "intermediate AMD." Outcome measures were superficial vessel density, deep vessel density, and choroidal thickness. A control group of healthy subjects was selected for the statistical comparisons. RESULTS: A total of 37 eyes of 37 dry AMDpatients were enrolled for the study. Fourteen of 37 eyes were classified as having early AMD, the remaining 23 of 37 eyes were classified as being affected by intermediate AMD. Superficial and deep vessel densities were 39.21% ± 10.67% and 43.84% ± 11.57%, respectively, in the control group and 28.30% ± 10.73% and 36.41% ± 12.30%, respectively, in AMDpatients (P = 0.001 and P = 0.017, respectively). Choroidal thickness was significantly reduced in AMDpatients. CONCLUSION: In the last years, several studies have reported vascular factors playing an important role in AMD pathogenesis. We demonstrated that both superficial and deep retinal plexuses are altered among patients affected by AMD. Interestingly, this alteration starts immediately at the intermediate AMD stage and also the choroidal thickness reduction.
Authors: Leonardo Mastropasqua; Enrico Borrelli; Paolo Carpineto; Lisa Toto; Luca Di Antonio; Peter A Mattei; Rodolfo Mastropasqua Journal: Int Ophthalmol Date: 2017-06-19 Impact factor: 2.031
Authors: Min Fang; Keri Strand; Juan Zhang; Matthew Totillo; Qi Chen; Joseph F Signorile; Hong Jiang; Jianhua Wang Journal: Exp Gerontol Date: 2020-10-22 Impact factor: 4.032
Authors: Rui Zhao; Acner Camino; Jie Wang; Ahmed M Hagag; Yansha Lu; Steven T Bailey; Christina J Flaxel; Thomas S Hwang; David Huang; Dengwang Li; Yali Jia Journal: Biomed Opt Express Date: 2017-10-17 Impact factor: 3.732
Authors: Sophie C Lee; Steven Tran; Aana Amin; Lawrence S Morse; Ala Moshiri; Susanna S Park; Glenn Yiu Journal: Am J Ophthalmol Date: 2019-12-16 Impact factor: 5.258
Authors: A C S Tan; G S Tan; A K Denniston; P A Keane; M Ang; D Milea; U Chakravarthy; C M G Cheung Journal: Eye (Lond) Date: 2017-09-08 Impact factor: 3.775