| Literature DB >> 26807413 |
Ting-Ting Qin1, Hai-Quan Kang1, Ping Ma1, Peng-Peng Li1, Lin-Yan Huang1, Bing Gu1.
Abstract
Bacteria can survive fluoroquinolone antibiotics (FQs) treatment by becoming resistant through a genetic change-mutation or gene acquisition. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation, which is repressed by LexA protein and derepressed by RecA protein. Here, we take a comprehensive review of the SOS gene network and its regulation on the fluoroquinolone resistance. As a unique survival mechanism, SOS may be an important factor influencing the outcome of antibiotic therapy in vivo.Entities:
Keywords: Fluoroquinolone resistance; SOS response; regulation
Year: 2015 PMID: 26807413 PMCID: PMC4701512 DOI: 10.3978/j.issn.2305-5839.2015.12.09
Source DB: PubMed Journal: Ann Transl Med ISSN: 2305-5839