Literature DB >> 26807413

SOS response and its regulation on the fluoroquinolone resistance.

Ting-Ting Qin1, Hai-Quan Kang1, Ping Ma1, Peng-Peng Li1, Lin-Yan Huang1, Bing Gu1.   

Abstract

Bacteria can survive fluoroquinolone antibiotics (FQs) treatment by becoming resistant through a genetic change-mutation or gene acquisition. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation, which is repressed by LexA protein and derepressed by RecA protein. Here, we take a comprehensive review of the SOS gene network and its regulation on the fluoroquinolone resistance. As a unique survival mechanism, SOS may be an important factor influencing the outcome of antibiotic therapy in vivo.

Entities:  

Keywords:  Fluoroquinolone resistance; SOS response; regulation

Year:  2015        PMID: 26807413      PMCID: PMC4701512          DOI: 10.3978/j.issn.2305-5839.2015.12.09

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN: 2305-5839


  94 in total

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6.  Structure of the LexA-DNA complex and implications for SOS box measurement.

Authors:  Adrianna P P Zhang; Ying Z Pigli; Phoebe A Rice
Journal:  Nature       Date:  2010-08-12       Impact factor: 49.962

Review 7.  Aeons of distress: an evolutionary perspective on the bacterial SOS response.

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Journal:  Nucleic Acids Res       Date:  2013-08-21       Impact factor: 16.971

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