BACKGROUND: Pharmacogenomics is the study of how genes affect a person's response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information. METHODS: Four resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs. RESULTS: There was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs. CONCLUSION: Lexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.
BACKGROUND: Pharmacogenomics is the study of how genes affect a person's response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information. METHODS: Four resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs. RESULTS: There was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs. CONCLUSION: Lexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.
Entities:
Keywords:
Biomarkers; Drug Information Services; Genetic Testing; Pharmacogenomics
Authors: Kelly E Caudle; Teri E Klein; James M Hoffman; Daniel J Muller; Michelle Whirl-Carrillo; Li Gong; Ellen M McDonagh; Katrin Sangkuhl; Caroline F Thorn; Matthias Schwab; Jose A G Agundez; Robert R Freimuth; Vojtech Huser; Ming Ta Michael Lee; Otito F Iwuchukwu; Kristine R Crews; Stuart A Scott; Mia Wadelius; Jesse J Swen; Rachel F Tyndale; C Michael Stein; Dan Roden; Mary V Relling; Marc S Williams; Samuel G Johnson Journal: Curr Drug Metab Date: 2014-02 Impact factor: 3.731
Authors: Nilofar Daneshi; Elizabeth Holliday; Stephen Hancock; Jennifer J Schneider; Rodney J Scott; John Attia; Elizabeth A Milward Journal: Pharmgenomics Pers Med Date: 2017-01-27
Authors: Sally H Preissner; Paolo Marchetti; Maurizio Simmaco; Björn O Gohlke; Andreas Eckert; Saskia Preissner; Robert Preissner Journal: Eur J Clin Pharmacol Date: 2021-12-27 Impact factor: 2.953