| Literature DB >> 26806338 |
Shinichi Yachida1, Laura D Wood2, Masami Suzuki3, Erina Takai3, Yasushi Totoki3, Mamoru Kato4, Claudio Luchini2, Yasuhito Arai3, Hiromi Nakamura3, Natsuko Hama3, Asmaa Elzawahry4, Fumie Hosoda3, Tomoki Shirota3, Nobuhiko Morimoto5, Kunio Hori5, Jun Funazaki5, Hikaru Tanaka6, Chigusa Morizane7, Takuji Okusaka7, Satoshi Nara8, Kazuaki Shimada8, Nobuyoshi Hiraoka9, Hirokazu Taniguchi9, Ryota Higuchi10, Minoru Oshima11, Keiichi Okano11, Seiko Hirono12, Masamichi Mizuma13, Koji Arihiro14, Masakazu Yamamoto10, Michiaki Unno13, Hiroki Yamaue12, Matthew J Weiss15, Christopher L Wolfgang15, Toru Furukawa16, Hitoshi Nakagama17, Bert Vogelstein18, Tohru Kiyono17, Ralph H Hruban19, Tatsuhiro Shibata20.
Abstract
Ampullary carcinomas are highly malignant neoplasms that can have either intestinal or pancreatobiliary differentiation. To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencing and DNA copy-number analysis on 60 ampullary carcinomas resected from clinically well-characterized Japanese and American patients. We next selected 92 genes and performed targeted sequencing to validate significantly mutated genes in an additional 112 cancers. The prevalence of driver gene mutations in carcinomas with the intestinal phenotype is different from those with the pancreatobiliary phenotype. We identified a characteristic significantly mutated driver gene (ELF3) as well as previously known driver genes (TP53, KRAS, APC, and others). Functional studies demonstrated that ELF3 silencing in normal human epithelial cells enhances their motility and invasion.Entities:
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Year: 2016 PMID： 26806338 PMCID： PMC5503303 DOI： 10.1016/j.ccell.2015.12.012
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743