Literature DB >> 2679902

Nobel Lecture. The purine path to chemotherapy.

G B Elion1.   

Abstract

Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.

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Year:  1989        PMID： 2679902     DOI： 10.1007/bf01119794

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  13 in total

Review 1.  Biosynthesis and Chemical Applications of Thioamides.

Authors:  Nilkamal Mahanta; D Miklos Szantai-Kis; E James Petersson; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2019-01-30       Impact factor: 5.100

2.  GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Authors:  Jessica L Chitty; Tayla L Tatzenko; Simon J Williams; Y Q Andre E Koh; Elizabeth C Corfield; Mark S Butler; Avril A B Robertson; Matthew A Cooper; Ulrike Kappler; Bostjan Kobe; James A Fraser
Journal:  J Biol Chem       Date:  2017-01-06       Impact factor: 5.157

3.  An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.

Authors:  Henry C Liu; Neema Jamshidi; Yuchen Chen; Satish A Eraly; Sai Yee Cho; Vibha Bhatnagar; Wei Wu; Kevin T Bush; Ruben Abagyan; Bernhard O Palsson; Sanjay K Nigam
Journal:  J Biol Chem       Date:  2016-07-20       Impact factor: 5.157

4.  Methylation of inorganic and organic selenium by the bacterial thiopurine methyltransferase.

Authors:  Lionel Ranjard; Claire Prigent-Combaret; Sylvie Nazaret; Benoit Cournoyer
Journal:  J Bacteriol       Date:  2002-06       Impact factor: 3.490

Review 5.  Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo.

Authors:  Alexander Keith Turbayne; Miles Patrick Sparrow
Journal:  Dig Dis Sci       Date:  2022-10-15       Impact factor: 3.487

Review 6.  Purine Acquisition and Synthesis by Human Fungal Pathogens.

Authors:  Jessica L Chitty; James A Fraser
Journal:  Microorganisms       Date:  2017-06-08

7.  MoImd4 mediates crosstalk between MoPdeH-cAMP signalling and purine metabolism to govern growth and pathogenicity in Magnaporthe oryzae.

Authors:  Lina Yang; Yanyan Ru; Xingjia Cai; Ziyi Yin; Xinyu Liu; Yuhan Xiao; Haifeng Zhang; Xiaobo Zheng; Ping Wang; Zhengguang Zhang
Journal:  Mol Plant Pathol       Date:  2019-01-11       Impact factor: 5.663

8.  Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.

Authors:  Maywan Hariono; Sy Bing Choi; Ros Fatihah Roslim; Mohamed Sufian Nawi; Mei Lan Tan; Ezatul Ezleen Kamarulzaman; Nornisah Mohamed; Rohana Yusof; Shatrah Othman; Noorsaadah Abd Rahman; Rozana Othman; Habibah A Wahab
Journal:  PLoS One       Date:  2019-01-24       Impact factor: 3.240

9.  The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease.

Authors:  Marius Vögelin; Luc Biedermann; Pascal Frei; Stephan R Vavricka; Sylvie Scharl; Jonas Zeitz; Michael C Sulz; Michael Fried; Gerhard Rogler; Michael Scharl
Journal:  PLoS One       Date:  2016-05-23       Impact factor: 3.240

Review 10.  Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug Monitoring.

Authors:  Sheng Zhang Lim; Eng Wee Chua
Journal:  Front Pharmacol       Date:  2018-10-08       Impact factor: 5.810
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