Kraig S Bower1, Rose K Sia2, Denise S Ryan2, Michael J Mines2, Darlene A Dartt2. 1. From The Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA (Bower), Warfighter Refractive Eye Surgery Program and Research Center at Fort Belvoir, Fort Belvoir, Virginia, USA (Sia, Ryan), Ophthalmology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA (Mines), Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA (Dartt). Electronic address: kbower5@jhmi.edu. 2. From The Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA (Bower), Warfighter Refractive Eye Surgery Program and Research Center at Fort Belvoir, Fort Belvoir, Virginia, USA (Sia, Ryan), Ophthalmology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA (Mines), Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA (Dartt).
Abstract
PURPOSE: To evaluate dry-eye manifestations after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) and determine the incidence and predictive factors of chronic dry eye using a set of dry-eye criteria. SETTING: Walter Reed Army Medical Center, Washington, DC, USA. DESIGN: Prospective, non-randomized clinical study. METHODS: Dry-eye evaluation was performed before and after surgery. Main outcome measures included dry-eye manifestations, incidence, and predictive factors of chronic dry eye. RESULTS: This study comprised 143 active-duty U.S. Army personnel, ages 29.9 ± 5.2 years, with myopia or myopic astigmatism (manifest spherical equivalent -3.83 ± 1.96 diopters) having PRK or LASIK. Schirmer scores, corneal sensitivity, ocular surface staining, surface regularity index, and responses to dry-eye questionnaire significantly changed over time after PRK. After LASIK, significant changes were observed in tear breakup time, corneal sensitivity, ocular surface staining, and responses to questionnaire. Twelve months postoperatively, 5.0% of PRK and 0.8% of LASIK participants developed chronic dry eye. Regression analysis showed that pre-operatively lower Schirmer score will significantly influence development of chronic dry eye after PRK, whereas preoperatively, lower Schirmer score or higher ocular surface staining score will significantly influence the occurrence of chronic dry eye after LASIK. CONCLUSIONS: Chronic dry eye was uncommon after PRK and LASIK. Ocular surface and tear-film characteristics during pre-operative examination might help to predict chronic dry-eye development in PRK and LASIK. FINANCIAL DISCLOSURE: The authors have no financial interest in any product, drug, instrument, or equipment discussed in this manuscript.
PURPOSE: To evaluate dry-eye manifestations after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) and determine the incidence and predictive factors of chronic dry eye using a set of dry-eye criteria. SETTING: Walter Reed Army Medical Center, Washington, DC, USA. DESIGN: Prospective, non-randomized clinical study. METHODS:Dry-eye evaluation was performed before and after surgery. Main outcome measures included dry-eye manifestations, incidence, and predictive factors of chronic dry eye. RESULTS: This study comprised 143 active-duty U.S. Army personnel, ages 29.9 ± 5.2 years, with myopia or myopic astigmatism (manifest spherical equivalent -3.83 ± 1.96 diopters) having PRK or LASIK. Schirmer scores, corneal sensitivity, ocular surface staining, surface regularity index, and responses to dry-eye questionnaire significantly changed over time after PRK. After LASIK, significant changes were observed in tear breakup time, corneal sensitivity, ocular surface staining, and responses to questionnaire. Twelve months postoperatively, 5.0% of PRK and 0.8% of LASIK participants developed chronic dry eye. Regression analysis showed that pre-operatively lower Schirmer score will significantly influence development of chronic dry eye after PRK, whereas preoperatively, lower Schirmer score or higher ocular surface staining score will significantly influence the occurrence of chronic dry eye after LASIK. CONCLUSIONS:Chronic dry eye was uncommon after PRK and LASIK. Ocular surface and tear-film characteristics during pre-operative examination might help to predict chronic dry-eye development in PRK and LASIK. FINANCIAL DISCLOSURE: The authors have no financial interest in any product, drug, instrument, or equipment discussed in this manuscript.
Authors: Cintia S De Paiva; Zhuo Chen; Douglas D Koch; M Bowes Hamill; Francis K Manuel; Sohela S Hassan; Kirk R Wilhelmus; Stephen C Pflugfelder Journal: Am J Ophthalmol Date: 2006-03 Impact factor: 5.258
Authors: Denise S Ryan; Kraig S Bower; Rose K Sia; Marie A Shatos; Robin S Howard; Michael J Mines; Richard D Stutzman; Darlene A Dartt Journal: J Cataract Refract Surg Date: 2016-08 Impact factor: 3.351
Authors: Antonio J Mateo Orobia; Paula Casas Pascual; José Á Cristóbal Bescós; Diana Perez García; Carlos Peiro Embid; M Ángeles Del Buey Sayas; Valentyna Korobko Kulikova; Noelia Lafuente Ojeda Journal: Clin Ophthalmol Date: 2017-02-16