Ali A Asadi-Pooya1, Marziyeh Tajvarpour2, Bahareh Vedadinezhad3, Mehrdad Emami4. 1. MD, Neurosciences Research Center, School of Medicine, Shiraz University of Medical Sciences, & Neurosciences Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, & Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. aliasadipooya@yahoo.com. 2. MD, Neurosciences Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. tajvarpoor@yahoo.com. 3. MD, Neurosciences Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. vedadibahare@gmail.com. 4. MD, Neurosciences Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. mehrdade1984@gmail.com.
Abstract
BACKGROUND: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies. METHODS: In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sciences from September 2008 to May 2013. We classified the patients with TLE as having mesial temporal sclerosis if they had clear signs of mesial temporal sclerosis and/or atrophy in their MRI and others who had any other MRI abnormality. RESULTS: A total of 174 patients were studied (including 105 patients with mTLE-HS and 69 patients with TLE due to other etiologies). Frequency of seizure types was not significantly different between these two groups. Earlier age at epilepsy onset (p= 0.005), a past history of febrile seizures (p= 0.010) and presence of affective auras (p= 0.008) were commonly seen in patients with mTLEHS, while auditory auras (p= 0.020) were more frequent in those with TLE due to other etiologies. CONCLUSION: The mainstay for making a correct diagnosis, when evaluating a patient with seizure, is having a standardized approach, particularly with regard to taking a detailed clinical history. One may find important clues in the clinical history (e.g., age at disease onset, detailed seizure description and past history) to make a correct diagnosis.
BACKGROUND: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies. METHODS: In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatientepilepsy clinic at Shiraz University of Medical Sciences from September 2008 to May 2013. We classified the patients with TLE as having mesial temporal sclerosis if they had clear signs of mesial temporal sclerosis and/or atrophy in their MRI and others who had any other MRI abnormality. RESULTS: A total of 174 patients were studied (including 105 patients with mTLE-HS and 69 patients with TLE due to other etiologies). Frequency of seizure types was not significantly different between these two groups. Earlier age at epilepsy onset (p= 0.005), a past history of febrile seizures (p= 0.010) and presence of affective auras (p= 0.008) were commonly seen in patients with mTLEHS, while auditory auras (p= 0.020) were more frequent in those with TLE due to other etiologies. CONCLUSION: The mainstay for making a correct diagnosis, when evaluating a patient with seizure, is having a standardized approach, particularly with regard to taking a detailed clinical history. One may find important clues in the clinical history (e.g., age at disease onset, detailed seizure description and past history) to make a correct diagnosis.
Authors: Darrell V Lewis; Shlomo Shinnar; Dale C Hesdorffer; Emilia Bagiella; Jacqueline A Bello; Stephen Chan; Yuan Xu; James MacFall; William A Gomes; Solomon L Moshé; Gary W Mathern; John M Pellock; Douglas R Nordli; L Matthew Frank; James Provenzale; Ruth C Shinnar; Leon G Epstein; David Masur; Claire Litherland; Shumei Sun Journal: Ann Neurol Date: 2014-03-01 Impact factor: 10.422
Authors: Taíssa Ferrari-Marinho; Luís Otávio S F Caboclo; Murilo M Marinho; Ricardo S Centeno; Rafael S C Neves; Maria Teresa C G Santana; Fernanda S Brito; Henrique Carrete Junior; Elza Márcia T Yacubian Journal: Epilepsy Behav Date: 2012-04-19 Impact factor: 2.937