N M Verweij1, A H W Schiphorst2, H A Maas3, D D E Zimmerman4, F van den Bos5, A Pronk2, I H M Borel Rinkes6, M E Hamaker7. 1. Department of Geriatric Medicine/Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands. nverweij@diakhuis.nl. 2. Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands. 3. Department of Geriatric Medicine, Elisabeth - Tweesteden Hospital, Tilburg, The Netherlands. 4. Department of Surgery, Elisabeth - Tweesteden Hospital, Tilburg, The Netherlands. 5. Department of Internal Medicine, Haga Hospital, The Hague, The Netherlands. 6. Department of Surgery, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands. 7. Department of Geriatric Medicine, Diakonessenhuis, Utrecht, The Netherlands.
Abstract
INTRODUCTION: Adequate decision-making in elderly colorectal cancer patients requires accurate information regarding risks of treatment. We analysed the outcome and survival of colorectal resections in the oldest old (≥85 years). METHODS: An analysis of the 2011-2012 data from two large nationwide registries: the Dutch Surgical Colorectal Audit (DSCA), containing all colorectal cancer resections, and the Netherlands Cancer Registry (NCR), containing survival data for all newly diagnosed malignancies. RESULTS: The study included more than 1200 patients aged ≥85 years (DSCA n = 1232, NCR n = 1206). The postoperative complication rate was 41 % in the oldest old. The frequency of cardiopulmonary complications rose rapidly with age, from 11 % in those <70 years to 38 % for the oldest old (p < 0.001). Postoperative 30-day mortality rate was 10 % in the oldest old. Three-month mortality was 14 % (compared with 3 % of patients <85 years; p < 0.001). One-year mortality was 24 % and 2-year mortality 36 %. After correction for expected mortality in the general population, excess mortality for the oldest old was 12 % in the first year and 3 % in the second year. CONCLUSIONS: In this study of more than 1200 colorectal cancer patients aged ≥85 years undergoing surgical resection, we found high rates of cardiopulmonary complications and excess mortality, particularly in the first year after surgery. We propose that these data could be incorporated into individualized treatment algorithms, which also include detailed information regarding the patients' health status.
INTRODUCTION: Adequate decision-making in elderly colorectal cancerpatients requires accurate information regarding risks of treatment. We analysed the outcome and survival of colorectal resections in the oldest old (≥85 years). METHODS: An analysis of the 2011-2012 data from two large nationwide registries: the Dutch Surgical Colorectal Audit (DSCA), containing all colorectal cancer resections, and the Netherlands Cancer Registry (NCR), containing survival data for all newly diagnosed malignancies. RESULTS: The study included more than 1200 patients aged ≥85 years (DSCA n = 1232, NCR n = 1206). The postoperative complication rate was 41 % in the oldest old. The frequency of cardiopulmonary complications rose rapidly with age, from 11 % in those <70 years to 38 % for the oldest old (p < 0.001). Postoperative 30-day mortality rate was 10 % in the oldest old. Three-month mortality was 14 % (compared with 3 % of patients <85 years; p < 0.001). One-year mortality was 24 % and 2-year mortality 36 %. After correction for expected mortality in the general population, excess mortality for the oldest old was 12 % in the first year and 3 % in the second year. CONCLUSIONS: In this study of more than 1200 colorectal cancerpatients aged ≥85 years undergoing surgical resection, we found high rates of cardiopulmonary complications and excess mortality, particularly in the first year after surgery. We propose that these data could be incorporated into individualized treatment algorithms, which also include detailed information regarding the patients' health status.
Authors: Linda Pang; Maxine de la Cruz; Jimin Wu; Diane Liu; Mujtaba Naqvi; Eduardo Bruera Journal: Support Care Cancer Date: 2019-02-23 Impact factor: 3.603
Authors: N M Verweij; E T D Souwer; A H W Schiphorst; H A Maas; J E A Portielje; A Pronk; F van den Bos; M E Hamaker Journal: Int J Colorectal Dis Date: 2017-09-20 Impact factor: 2.571
Authors: N M Verweij; M E Hamaker; D D E Zimmerman; Y T van Loon; F van den Bos; A Pronk; I H M Borel Rinkes; A H W Schiphorst Journal: Int J Colorectal Dis Date: 2016-10-08 Impact factor: 2.571
Authors: Federico Mazzotti; Alessandro Cucchetti; Yvette H M Claassen; Amanda C R K Bos; Esther Bastiaannet; Giorgio Ercolani; Jan Willem T Dekker Journal: World J Surg Date: 2019-08 Impact factor: 3.352
Authors: Yara Backes; Leon Mg Moons; Marco R Novelli; Jeroen D van Bergeijk; John N Groen; Tom Cj Seerden; Matthijs P Schwartz; Wouter H de Vos Tot Nederveen Cappel; Bernhard Wm Spanier; Joost Mj Geesing; Koen Kessels; Marjon Kerkhof; Peter D Siersema; G Johan A Offerhaus; Anya N Milne; Miangela M Lacle Journal: Mod Pathol Date: 2016-10-07 Impact factor: 7.842