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Literature DB >> 26782096

Virus-based nanoparticles as platform technologies for modern vaccines.

Karin L Lee¹, Richard M Twyman², Steven Fiering³, Nicole F Steinmetz^1,4,5,6,7.

Abstract

Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus-based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious diseases, chronic diseases, cancer, and addiction. WIREs Nanomed Nanobiotechnol 2016, 8:554-578. doi: 10.1002/wnan.1383 For further resources related to this article, please visit the WIREs website.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：
Vaccines

Year: 2016 PMID： 26782096 PMCID： PMC5638654 DOI： 10.1002/wnan.1383

Source DB: PubMed Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol ISSN： 1939-0041

191 in total

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7. The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

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10. Efficacy of RG1-VLP vaccination against infections with genital and cutaneous human papillomaviruses.

Authors: Christina Schellenbacher; Kihyuck Kwak; Dieter Fink; Saeed Shafti-Keramat; Bettina Huber; Christoph Jindra; Helena Faust; Joakim Dillner; Richard B S Roden; Reinhard Kirnbauer
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23 in total

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2. A Viral Nanoparticle Cancer Vaccine Delays Tumor Progression and Prolongs Survival in a HER2⁺ Tumor Mouse Model.

Authors: Sourabh Shukla; Michal Jandzinski; Chao Wang; Xingjian Gong; Kristen Weber Bonk; Ruth A Keri; Nicole F Steinmetz
Journal: Adv Ther (Weinh) Date: 2019-01-29

Review 3. Plant viruses and bacteriophages for drug delivery in medicine and biotechnology.

Authors: Anna E Czapar; Nicole F Steinmetz
Journal: Curr Opin Chem Biol Date: 2017-04-17 Impact factor: 8.822

4. Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs.

Authors: Hema Masarapu; Bindi K Patel; Paul L Chariou; He Hu; Neetu M Gulati; Bradley L Carpenter; Reza A Ghiladi; Sourabh Shukla; Nicole F Steinmetz
Journal: Biomacromolecules Date: 2017-11-16 Impact factor: 6.988

5. Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer.

Authors: P Jack Hoopes; Courtney M Mazur; Bjorn Osterberg; Ailin Song; David J Gladstone; Nicole F Steinmetz; Frank A Veliz; Alicea A Bursey; Robert J Wagner; Steven N Fiering
Journal: Proc SPIE Int Soc Opt Eng Date: 2017-02-20

6. Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer.

Authors: P Jack Hoopes; Karen L Moodie; Alicia A Petryk; James D Petryk; Shawntel Sechrist; David J Gladstone; Nicole F Steinmetz; Frank A Veliz; Alicea A Bursey; Robert J Wagner; Ashish Rajan; Danielle Dugat; Margaret Crary-Burney; Steven N Fiering
Journal: Proc SPIE Int Soc Opt Eng Date: 2017-02-22