R P Narayanan1, A D Weeks2, S Quenby3, D Rycroft4, A Hart5, H Longworth6, M Charnley7, J Abayomi7, J Topping6, M A Turner2, J P H Wilding1. 1. Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. 2. Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. 3. Biomedical Research Unit in Reproductive Health, University of Warwick, Coventry, UK. 4. Fit for Birth, School of Reproductive and Developmental Medicine, Liverpool Women's Hospital, Liverpool, UK. 5. Lancaster Medical School, Clinical Research Hub, Lancaster University, Lancaster, Lancashire, UK. 6. Liverpool Women's NHS Foundation Trust, Liverpool, UK. 7. Faculty of Education, Health & Community, Liverpool John Moores University, Liverpool, UK.
Abstract
UNLABELLED: The 'Fit for Birth' study aimed to explore patterns of gestational weight gain and their relationship with pregnancy outcomes. The study had three aims: 1. To explore the feasibility of conducting a large cohort study in this setting. 2. To describe patterns of weight gain through pregnancy in obese women. 3. To explore associations of weight change during pregnancy with outcomes. STUDY POPULATION: Pregnant women with a BMI ≥ 30 kg m(-2) at first antenatal clinic visit. METHODS: This was a single centre pilot observational study based at the Liverpool Women's Hospital, a large UK maternity hospital.Women were recruited into the study at their antenatal booking visit and had weights measured throughout pregnancy. Patterns of weight gain were described and related to maternal and neonatal outcomes. MAIN OUTCOME MEASURE: The primary outcome was a composite measure consisting of any of 12 adverse maternal and foetal outcomes. This was compared by categorized pregnancy weight gain (<0 kg, 0-5 kg, 5.1-9 kg and >9 kg). RESULTS: Eight hundred and twenty four women consented to participation between June 2009 and June 2010. Weight data were collected on 756 women. Only 385 women had weights measured in all three study assessment periods (6-20 weeks, 20 + 1 to 32 weeks and >32 weeks gestation) while 427 women had weights measured in period 3. Individual patterns of weight gain varied widely and missing data were common and non-random. There was a significant association between increased weight gain during pregnancy and poor maternal and foetal outcome. CONCLUSIONS: Weight gain in obese women during pregnancy can be highly variable. Our study supports an association between increased weight gain in pregnancy and adverse perinatal outcomes.
UNLABELLED: The 'Fit for Birth' study aimed to explore patterns of gestational weight gain and their relationship with pregnancy outcomes. The study had three aims: 1. To explore the feasibility of conducting a large cohort study in this setting. 2. To describe patterns of weight gain through pregnancy in obesewomen. 3. To explore associations of weight change during pregnancy with outcomes. STUDY POPULATION: Pregnant women with a BMI ≥ 30 kg m(-2) at first antenatal clinic visit. METHODS: This was a single centre pilot observational study based at the Liverpool Women's Hospital, a large UK maternity hospital.Women were recruited into the study at their antenatal booking visit and had weights measured throughout pregnancy. Patterns of weight gain were described and related to maternal and neonatal outcomes. MAIN OUTCOME MEASURE: The primary outcome was a composite measure consisting of any of 12 adverse maternal and foetal outcomes. This was compared by categorized pregnancy weight gain (<0 kg, 0-5 kg, 5.1-9 kg and >9 kg). RESULTS: Eight hundred and twenty four women consented to participation between June 2009 and June 2010. Weight data were collected on 756 women. Only 385 women had weights measured in all three study assessment periods (6-20 weeks, 20 + 1 to 32 weeks and >32 weeks gestation) while 427 women had weights measured in period 3. Individual patterns of weight gain varied widely and missing data were common and non-random. There was a significant association between increased weight gain during pregnancy and poor maternal and foetal outcome. CONCLUSIONS:Weight gain in obesewomen during pregnancy can be highly variable. Our study supports an association between increased weight gain in pregnancy and adverse perinatal outcomes.
Authors: Sarah J Pugh; Paul S Albert; Sungduk Kim; William Grobman; Stefanie N Hinkle; Roger B Newman; Deborah A Wing; Katherine L Grantz Journal: Am J Obstet Gynecol Date: 2017-05-11 Impact factor: 8.661
Authors: Mary T McCann; Lisa Newson; Catriona Burden; Jane S Rooney; Margaret S Charnley; Julie C Abayomi Journal: Matern Child Nutr Date: 2017-09-25 Impact factor: 3.092
Authors: James Kent; William C Dodson; Allen Kunselman; Jaimey Pauli; Alicia Stone; Michael P Diamond; Christos Coutifaris; William D Schlaff; Ruben Alvero; Peter Casson; Gregory M Christman; R Mitchell Rosen; Karl R Hansen; Randall D Robinson; Valerie Baker; Rebecca Usadi; Nanette Santoro; Heping Zhang; Esther Eisenberg; Richard S Legro Journal: J Clin Endocrinol Metab Date: 2018-11-01 Impact factor: 5.958