L A Bazzano1, T Hu1, S M Bertisch2, L Yao3, E W Harville1, J Gustat1, W Chen1, L S Webber4, T Shu1, S Redline5,6. 1. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. 2. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. 3. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA. 4. Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. 5. Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 6. Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Abstract
BACKGROUND: Obese adults have a higher risk of obstructive sleep apnoea (OSA); however, the relationship between childhood obesity and adult OSA risk is unclear. Objectives This study aimed to examine overweight/obesity (OW) in childhood and risk of OSA in middle age. METHODS: Childhood OW status was classified as never OW, weight cycling, persistent OW and incident OW. After 35 years of follow-up, high risk for OSA was determined by a positive score in ≥2 domains on the Berlin Questionnaire with obesity removed from scoring. RESULTS: At initial assessment, mean (SD) age was 9.9 (2.9) years, and 23.9% were OW. Overall, 25.7% had scores indicating a high risk for OSA. Compared with participants who were never OW, those with persistent OW and incident OW were 1.36 (95%CI: 1.04-1.77) and 1.47 (1.11-1.96) times more likely to be high risk for OSA, after adjustment for multiple risk factors and adult OW status. Participants with an OW duration of 1-4 years, 5-8 years, and 8+ years were 0.96 (0.44-2.09), 1.20 (0.70-2.04) and 1.52 (1.22-1.90) times more likely to be high risk for OSA compared with those who were never OW (P for trend: 0.0002). CONCLUSIONS: These results suggest that childhood OW is associated with a high risk of OSA in middle age.
BACKGROUND:Obese adults have a higher risk of obstructive sleep apnoea (OSA); however, the relationship between childhood obesity and adult OSA risk is unclear. Objectives This study aimed to examine overweight/obesity (OW) in childhood and risk of OSA in middle age. METHODS: Childhood OW status was classified as never OW, weight cycling, persistent OW and incident OW. After 35 years of follow-up, high risk for OSA was determined by a positive score in ≥2 domains on the Berlin Questionnaire with obesity removed from scoring. RESULTS: At initial assessment, mean (SD) age was 9.9 (2.9) years, and 23.9% were OW. Overall, 25.7% had scores indicating a high risk for OSA. Compared with participants who were never OW, those with persistent OW and incident OW were 1.36 (95%CI: 1.04-1.77) and 1.47 (1.11-1.96) times more likely to be high risk for OSA, after adjustment for multiple risk factors and adult OW status. Participants with an OW duration of 1-4 years, 5-8 years, and 8+ years were 0.96 (0.44-2.09), 1.20 (0.70-2.04) and 1.52 (1.22-1.90) times more likely to be high risk for OSA compared with those who were never OW (P for trend: 0.0002). CONCLUSIONS: These results suggest that childhood OW is associated with a high risk of OSA in middle age.
Authors: Mark J Kohler; Swetlana Thormaehlen; J Declan Kennedy; Yvonne Pamula; Cameron J van den Heuvel; Kurt Lushington; A James Martin Journal: J Clin Sleep Med Date: 2009-12-15 Impact factor: 4.062
Authors: Diane S Lauderdale; Kristen L Knutson; Lijing L Yan; Paul J Rathouz; Stephen B Hulley; Steve Sidney; Kiang Liu Journal: Am J Epidemiol Date: 2006-06-01 Impact factor: 4.897
Authors: Mercedes de Onis; Adelheid W Onyango; Elaine Borghi; Amani Siyam; Chizuru Nishida; Jonathan Siekmann Journal: Bull World Health Organ Date: 2007-09 Impact factor: 9.408
Authors: Edward O Bixler; Alexandros N Vgontzas; Hung-Mo Lin; Duanping Liao; Susan Calhoun; Antonio Vela-Bueno; Fred Fedok; Vukmir Vlasic; Gavin Graff Journal: Sleep Date: 2009-06 Impact factor: 5.849
Authors: L McDonald; J Wardle; C H Llewellyn; L Johnson; C H M van Jaarsveld; H Syrad; A Fisher Journal: Pediatr Obes Date: 2015-01-07 Impact factor: 4.000
Authors: Elizabeth Anne Bennett; Rachel Pearl Kolko; Lichun Chia; Jennifer Padden Elliott; Melissa Ann Kalarchian Journal: West J Nurs Res Date: 2017-03-28 Impact factor: 1.967