Literature DB >> 26780498

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.

Suresh Kumar Poovathingal1,2, Nataly Kravchenko-Balasha1,3, Young Shik Shin1, Raphael David Levine4,5, James R Heath1.   

Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  carcinogenesis; microfluidics; phase transition; single-cell proteomics; steady state

Mesh：

Substances：

Year:  2016        PMID： 26780498      PMCID： PMC4886749          DOI： 10.1002/smll.201501178

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  34 in total

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4.  Quantifying the Waddington landscape and biological paths for development and differentiation.

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-02       Impact factor: 11.205

5.  Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.

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  8 in total

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2.  Personalized disease signatures through information-theoretic compaction of big cancer data.

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5.  Unveil early-stage nanocytotoxicity by a label-free single cell pH nanoprobe.

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6.  Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance.

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7.  Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.

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  8 in total

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