Lei Pan1, Xiaomei Xie2, Dayue Liu3, Dunqiang Ren4, Yongzhong Guo5. 1. Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China. 2. Department of Radiotherapy, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu, 221009, China. 3. Department of Respiratory Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, 199 South Jiefang Road, Xuzhou, Jiangsu, 221009, China. 4. Department of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China. 5. Department of Respiratory Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, 199 South Jiefang Road, Xuzhou, Jiangsu, 221009, China. yongzhguo@sina.cn.
Abstract
PURPOSE: A meta-analysis of prospective cohort studies was conducted to clarify the association between obstructive sleep apnoea (OSA) and future risk of all-cause mortality. METHODS: Eligible studies were identified by searching the PubMed and EMBASE databases up to July 2015. Pooled hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were calculated to estimate the association between OSA and risk of all-cause mortality. Sources of heterogeneity were identified by subgroup and meta-regression analyses. RESULTS: Twelve prospective cohort studies involving 34,382 participants were included in this meta-analysis. The pooled HR of all-cause mortality was 1.262 (95 % CI 1.093-1.431) with significant heterogeneity. Subgroup analyses indicated that the pooled HRs of all-cause mortality in patients with mild, moderate and severe OSA were 0.945 (95 % CI 0.810-1.081), 1.178 (95 % CI 0.978-1.378) and 1.601 (95 % CI 1.298-1.902), respectively. OSA severity could be a possible sources of heterogeneity. Existing publication bias produced a minor contribution to effect size. CONCLUSION: Severe, but not mild to moderate, OSA is significantly associated with increased risk of all-cause mortality.
PURPOSE: A meta-analysis of prospective cohort studies was conducted to clarify the association between obstructive sleep apnoea (OSA) and future risk of all-cause mortality. METHODS: Eligible studies were identified by searching the PubMed and EMBASE databases up to July 2015. Pooled hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were calculated to estimate the association between OSA and risk of all-cause mortality. Sources of heterogeneity were identified by subgroup and meta-regression analyses. RESULTS: Twelve prospective cohort studies involving 34,382 participants were included in this meta-analysis. The pooled HR of all-cause mortality was 1.262 (95 % CI 1.093-1.431) with significant heterogeneity. Subgroup analyses indicated that the pooled HRs of all-cause mortality in patients with mild, moderate and severe OSA were 0.945 (95 % CI 0.810-1.081), 1.178 (95 % CI 0.978-1.378) and 1.601 (95 % CI 1.298-1.902), respectively. OSA severity could be a possible sources of heterogeneity. Existing publication bias produced a minor contribution to effect size. CONCLUSION: Severe, but not mild to moderate, OSA is significantly associated with increased risk of all-cause mortality.
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