Literature DB >> 2677754

Cooperative tandem binding of met repressor of Escherichia coli.

S E Phillips1, I Manfield, I Parsons, B E Davidson, J B Rafferty, W S Somers, D Margarita, G N Cohen, I Saint-Girons, P G Stockley.   

Abstract

We present biochemical and genetic data to support the hypothesis that the Escherichia coli met repressor, MetJ, binds to synthetic and natural operator sequences in tandem arrays such that repression depends not only on the affinity of the DNA-protein interaction, but also on protein-protein contacts along the tandem array. This represents a novel form of regulatory switch. Furthermore, there seems to be homology between the organization of the met and trp operators.

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Year:  1989        PMID： 2677754     DOI： 10.1038/341711a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  26 in total

1.  The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster.

Authors:  József Gál; Attila Szvetnik; Róbert Schnell; Miklós Kálmán
Journal:  J Bacteriol       Date:  2002-09       Impact factor: 3.490

2.  Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats.

Authors:  Ana B de la Hoz; Florencia Pratto; Rolf Misselwitz; Christian Speck; Wilhelm Weihofen; Karin Welfle; Wolfram Saenger; Heinz Welfle; Juan C Alonso
Journal:  Nucleic Acids Res       Date:  2004-06-09       Impact factor: 16.971

3.  Restored DNA-binding of the cAMP-CRP activator complex reestablishes negative regulation by the CytR repressor in the deoP2 promoter in Escherichia coli.

Authors:  L Søgaard-Andersen; P Valentin-Hansen
Journal:  Mol Gen Genet       Date:  1991-12

4.  Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor.

Authors:  Ferenc Marincs; Iain W Manfield; Jonathan A Stead; Kenneth J McDowall; Peter G Stockley
Journal:  Biochem J       Date:  2006-06-01       Impact factor: 3.857

Review 5.  Structural aspects of protein-DNA recognition.

Authors:  P S Freemont; A N Lane; M R Sanderson
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

6.  The Escherichia coli K-12 metJ193 allele contains a point mutation which alters the hydrophobic pocket responsible for in vitro binding of S-adenosylmethionine: effects on cell growth and induction of met regulon expression.

Authors:  C D Collier; J R Johnson
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

Review 7.  Methods for the analysis of DNA-protein interactions.

Authors:  M J Guille; G G Kneale
Journal:  Mol Biotechnol       Date:  1997-08       Impact factor: 2.695

8.  Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.

Authors:  T C Lee; K L Chow; P Fang; R J Schwartz
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

Review 9.  Functions of the gene products of Escherichia coli.

Authors:  M Riley
Journal:  Microbiol Rev       Date:  1993-12

10.  Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA.

Authors:  Catherine Joce; Jamie Caryl; Peter G Stockley; Stuart Warriner; Adam Nelson
Journal:  Org Biomol Chem       Date:  2008-12-19       Impact factor: 3.876
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