Jonathan M Fishman1,2, Jenny Long1, Markus Gugatschka3, Paolo De Coppi1, Shigeru Hirano4, Stellan Hertegard5, Susan L Thibeault6, Martin A Birchall2. 1. UCL Institute of Child Health, London, United Kingdom. 2. UCL Ear Institute and Royal National Throat, Nose and Ear Hospital and, London, United Kingdom. 3. Department of Phoniatrics, ENT University Hospital Graz, Medical University Graz, Graz, Austria. 4. Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 5. Department of Otorhinolaryngology, Karolinska Institutet Clintec, Karolinska University Hospital Huddinge, Stockholm, Sweden. 6. Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research, Madison, Wisconsin, U.S.A.
Abstract
OBJECTIVES/HYPOTHESIS: Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting development in this field and has the potential to further enhance VF recovery beyond conventional treatments. Our aim in this review is to discuss advances in the field of regenerative medicine; that is, advances in the process of replacing, engineering, or regenerating the VF through utilization of stem cells, with the intention of restoring normal VF structure and function. DATA SOURCES: English literature (1946-2015) review. METHODS: We conducted a systematic review of MEDLINE for cases and studies of VF tissue engineering utilizing stem cells. RESULTS: The three main approaches by which regenerative medicine is currently applied to VF regeneration include cell therapy, scaffold development, and utilization of growth factors. CONCLUSION: Exciting advances have been made in stem cell biology in recent years, including use of induced pluripotent stem cells. We expect such advances to be translated into the field in the forthcoming years. Laryngoscope, 126:1865-1870, 2016.
OBJECTIVES/HYPOTHESIS: Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting development in this field and has the potential to further enhance VF recovery beyond conventional treatments. Our aim in this review is to discuss advances in the field of regenerative medicine; that is, advances in the process of replacing, engineering, or regenerating the VF through utilization of stem cells, with the intention of restoring normal VF structure and function. DATA SOURCES: English literature (1946-2015) review. METHODS: We conducted a systematic review of MEDLINE for cases and studies of VF tissue engineering utilizing stem cells. RESULTS: The three main approaches by which regenerative medicine is currently applied to VF regeneration include cell therapy, scaffold development, and utilization of growth factors. CONCLUSION: Exciting advances have been made in stem cell biology in recent years, including use of induced pluripotent stem cells. We expect such advances to be translated into the field in the forthcoming years. Laryngoscope, 126:1865-1870, 2016.
Authors: Josh D Erndt-Marino; Andrea C Jimenez-Vergara; Patricia Diaz-Rodriguez; Jonathan Kulwatno; Juan Felipe Diaz-Quiroz; Susan Thibeault; Mariah S Hahn Journal: J Biomed Mater Res B Appl Biomater Date: 2017-06-05 Impact factor: 3.368
Authors: Vibe Lindeblad Wingstrand; Christian Grønhøj Larsen; David H Jensen; Kristian Bork; Lars Sebbesen; Jesper Balle; Anne Fischer-Nielsen; Christian von Buchwald Journal: PLoS One Date: 2016-09-15 Impact factor: 3.240