Literature DB >> 2677210

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

E Sonoda1, R Matsumoto, Y Hitoshi, T Ishii, M Sugimoto, S Araki, A Tominaga, N Yamaguchi, K Takatsu.   

Abstract

Effects of transforming growth factor beta (TGF-beta) on IgA production by LPS-stimulated B cells have been studied. TGF-beta itself could augment polyclonal IgA production in concomitant inhibition of polyclonal IgM and IgG1 production. Furthermore, TGF-beta and IL-5 additively augmented IgA production. TGF-beta exerted its activity early in the culture (by 2 d in a 5-d culture) and IL-5 was required late in the culture. Surface IgA- (sIgA-) B cells responded to TGF-beta for the development of IgA-secreting cells. By contrast, sIgA+ B cells, but not sIgA- B cells, responded to IL-5 for IgA production. These results suggest that TGF-beta has a differential role in the induction of IgA production from IL-5 on murine-activated B cells.

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Year:  1989        PMID： 2677210      PMCID： PMC2189486          DOI： 10.1084/jem.170.4.1415

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  14 in total

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Authors:  D A Lebman; R L Coffman
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Review 3.  Regulation of B-cell growth and differentiation by soluble factors.

Authors:  M Howard; W E Paul
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4.  Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

Authors:  R Derynck; J A Jarrett; E Y Chen; D H Eaton; J R Bell; R K Assoian; A B Roberts; M B Sporn; D V Goeddel
Journal:  Nature       Date:  1985 Aug 22-28       Impact factor: 49.962

5.  BCGFII activity on activated B cells of a purified murine T cell-replacing factor (TRF) from a T cell hybridoma (B151K12).

Authors:  N Harada; Y Kikuchi; A Tominaga; S Takaki; K Takatsu
Journal:  J Immunol       Date:  1985-06       Impact factor: 5.422

6.  Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

Authors:  K Takatsu; K Tanaka; A Tominaga; Y Kumahara; T Hamaoka
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7.  Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

Authors:  P D Murray; D T McKenzie; S L Swain; M F Kagnoff
Journal:  J Immunol       Date:  1987-10-15       Impact factor: 5.422

8.  Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Authors:  J H Kehrl; A B Roberts; L M Wakefield; S Jakowlew; M B Sporn; A S Fauci
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422

9.  Beta transforming growth factors are potential regulators of B lymphopoiesis.

Authors:  G Lee; L R Ellingsworth; S Gillis; R Wall; P W Kincade
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307

10.  Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B cells to sIgA B cells in vitro.

Authors:  H Kawanishi; L E Saltzman; W Strober
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307
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6.  Altered production of IgE and IgA induced by IL-4 in peripheral blood mononuclear cells from patients with IgA nephropathy.

Authors:  N Yano; M Endoh; M Miyazaki; F Yamauchi; Y Nomoto; H Sakai
Journal:  Clin Exp Immunol       Date:  1992-05       Impact factor: 4.330

Review 7.  The role of transforming growth factor-beta in inflammatory processes.

Authors:  S M Wahl
Journal:  Immunol Res       Date:  1991       Impact factor: 2.829

8.  Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide.

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Review 9.  Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases.

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10.  Transforming growth factor-beta 1 enhances the generation of allospecific cytotoxic T lymphocytes.

Authors:  S Kondo; K Isobe; N Ishiguro; I Nakashima; T Miura
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