BACKGROUND: Smoking is well-known as a risk factor for esophageal squamous cell carcinoma. However, little is known about the effect of this factor on survival. METHODS: Esophageal cancer patients who underwent esophagectomy without any preoperative therapy were retrospectively reviewed. Patients' postoperative overall and disease-free survivals were compared between 2 groups (non-heavy smokers and heavy smokers). RESULTS: A total of 109 cases were evaluated in this study. The 5-year OS rate of the non-heavy smokers was 53.2% and 32.3% for the heavy group. The 5-year DFS rate of the non-heavy smokers was 51.1% and 27.4% for the heavy group. Kaplan-Meier survival analysis revealed that heavy smokers had significantly poorer OS (P=0.018) and DFS (P=0.009) than non-heavy smokers. In multivariate analysis, smoking was found to be an independent prognostic factor for OS (P=0.003; HR: 2.186; 95% CI: 1.309-3.650) and DFS (P=0.001; HR: 2.471; 95% CI: 1.467-4.163). CONCLUSION: Smoking was associated with survival among patients with ESCC, and it was recognized as an independent factor in both OS and DFS.
BACKGROUND: Smoking is well-known as a risk factor for esophageal squamous cell carcinoma. However, little is known about the effect of this factor on survival. METHODS:Esophageal cancerpatients who underwent esophagectomy without any preoperative therapy were retrospectively reviewed. Patients' postoperative overall and disease-free survivals were compared between 2 groups (non-heavy smokers and heavy smokers). RESULTS: A total of 109 cases were evaluated in this study. The 5-year OS rate of the non-heavy smokers was 53.2% and 32.3% for the heavy group. The 5-year DFS rate of the non-heavy smokers was 51.1% and 27.4% for the heavy group. Kaplan-Meier survival analysis revealed that heavy smokers had significantly poorer OS (P=0.018) and DFS (P=0.009) than non-heavy smokers. In multivariate analysis, smoking was found to be an independent prognostic factor for OS (P=0.003; HR: 2.186; 95% CI: 1.309-3.650) and DFS (P=0.001; HR: 2.471; 95% CI: 1.467-4.163). CONCLUSION: Smoking was associated with survival among patients with ESCC, and it was recognized as an independent factor in both OS and DFS.
Authors: Aaron P Thrift; Christina M Nagle; Paul P Fahey; Anne Russell; Bernard M Smithers; David I Watson; David C Whiteman Journal: Int J Cancer Date: 2012-02-28 Impact factor: 7.396
Authors: James R Ramus; Piers A C Gatenby; Christine P J Caygill; Anthony Watson; Marc C Winslet Journal: Eur J Cancer Prev Date: 2012-11 Impact factor: 2.497
Authors: Lindsey A Torre; Freddie Bray; Rebecca L Siegel; Jacques Ferlay; Joannie Lortet-Tieulent; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2015-02-04 Impact factor: 508.702
Authors: Michael C Otterstatter; James D Brierley; Prithwish De; Larry F Ellison; Maureen Macintyre; Loraine D Marrett; Robert Semenciw; Hannah K Weir Journal: Can J Gastroenterol Date: 2012-10 Impact factor: 3.522