Literature DB >> 26770129

Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.

Katarzyna Maresz1.   

Abstract

Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks.

Entities:  

Year:  2015        PMID: 26770129      PMCID: PMC4566462     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN: 1546-993X


  59 in total

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Journal:  JAMA Intern Med       Date:  2013-04-22       Impact factor: 21.873

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Journal:  Blood       Date:  2006-12-07       Impact factor: 22.113

7.  Assessments of arterial stiffness and endothelial function using pulse wave analysis.

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Journal:  Int J Vasc Med       Date:  2012-05-14

Review 8.  Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis.

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Review 9.  Cardiovascular effects of calcium supplements.

Authors:  Ian R Reid
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Review 10.  Intima media thickness, pulse wave velocity, and flow mediated dilation.

Authors:  Rosa Maria Bruno; Elisabetta Bianchini; Francesco Faita; Stefano Taddei; Lorenzo Ghiadoni
Journal:  Cardiovasc Ultrasound       Date:  2014-08-23       Impact factor: 2.062

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  12 in total

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3.  Determination of vitamins K1 , MK-4, and MK-7 in human serum of postmenopausal women by HPLC with fluorescence detection.

Authors:  Eva Klapkova; Jana Cepova; Katerina Dunovska; Richard Prusa
Journal:  J Clin Lab Anal       Date:  2018-01-15       Impact factor: 2.352

4.  Calcium prescription by Indian orthopaedic surgeons: A survey and a review of literature.

Authors:  Binoti Sheth; S Akil Prabhakar; Pankaj Pawar; Himanshu Ganwir; Sameer Panchal; Akash Jain
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Review 5.  Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods.

Authors:  Daniel M Linares; Carolina Gómez; Erica Renes; José M Fresno; María E Tornadijo; R P Ross; Catherine Stanton
Journal:  Front Microbiol       Date:  2017-05-18       Impact factor: 5.640

Review 6.  Vitamin K2 Needs an RDI Separate from Vitamin K1.

Authors:  Asim Cengiz Akbulut; Angelina Pavlic; Ploingarm Petsophonsakul; Maurice Halder; Katarzyna Maresz; Rafael Kramann; Leon Schurgers
Journal:  Nutrients       Date:  2020-06-21       Impact factor: 5.717

7.  Effects of a novel nutraceutical combination (BruMeChol™) in subjects with mild hypercholesterolemia: study protocol of a randomized, double-blind, controlled trial.

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Journal:  Trials       Date:  2020-07-06       Impact factor: 2.279

Review 8.  A comprehensive overview on osteoporosis and its risk factors.

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Journal:  Ther Clin Risk Manag       Date:  2018-11-06       Impact factor: 2.423

Review 9.  Perspective: Evidence before Enthusiasm-A Critical Review of the Potential Cardiovascular Benefits of Vitamin K.

Authors:  M Kyla Shea; Kathleen L Berkner; Guylaine Ferland; Xueyan Fu; Rachel M Holden; Sarah L Booth
Journal:  Adv Nutr       Date:  2021-06-01       Impact factor: 8.701

10.  Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study.

Authors:  Agustin Cerani; Sirui Zhou; Vincenzo Forgetta; John A Morris; Katerina Trajanoska; Fernando Rivadeneira; Susanna C Larsson; Karl Michaëlsson; J Brent Richards
Journal:  BMJ       Date:  2019-08-01
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