Christoph Bickel1, Renate B Schnabel2, Tanja Zeller2, Karl J Lackner3, Hans J Rupprecht4, Stefan Blankenberg2, Christoph Sinning2, Dirk Westermann2. 1. a Department of Internal Medicine , Federal Armed Forces Central Hospital , Koblenz , Germany. 2. b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany. 3. c Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz , Mainz , Germany. 4. d Department of Medicine II , GPR Rüsselsheim , Rüsselsheim , Germany.
Abstract
CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions. OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907). METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years. RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients. CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.
CONTEXT: Leptin is produced in white adipose tissue, but also in humancoronary atherosclerotic lesions. OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907). METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years. RESULTS:Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients. CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.