Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Increased expression of SOX4 is associated with colorectal cancer progression.

Literature DB >> 26768610

Increased expression of SOX4 is associated with colorectal cancer progression.

Baochun Wang^1,2, Yixiong Li³, Fengbo Tan¹, Zhanxiang Xiao².

Abstract

Sex-determining region Y-related high-mobility group box 4 (SOX4) has been proven to serve as a critical role in cancer progression. However, the pathological role of SOX4 in colorectal cancer (CRC) remains unknown. The aim of this study was to investigate the role of SOX4 in CRC. In this study, we investigated the expression of SOX4 in CRC tissues by immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blot. We also evaluated the effect of SOX4 on cell proliferation and invasion by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and transwell assay. The SOX4 messenger RNA (mRNA) and protein expression were markedly higher in CRC tissues compared with adjacent normal mucosa tissues. Inhibition of SOX4 could suppress CRC cell proliferation, and invasion in vitro. Our findings indicate that targeting SOX4 might provide a new therapeutic modality for the treatment of CRC patients.

Entities: Chemical Disease Gene Species

Keywords: Colorectal cancer; EMT; Invasion; Proliferation; SOX4; Targeted therapy

Mesh：

Substances：

Year: 2016 PMID： 26768610 DOI： 10.1007/s13277-015-4756-5

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

24 in total

Review 1. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer.

Authors: David A Lieberman; Douglas K Rex; Sidney J Winawer; Francis M Giardiello; David A Johnson; Theodore R Levin
Journal: Gastroenterology Date: 2012-07-03 Impact factor: 22.682

2. SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression.

Authors: Jianchao Zhang; Qian Liang; Yang Lei; Min Yao; Lili Li; Xiaoge Gao; Jingxin Feng; Yu Zhang; Hongwen Gao; Dong-Xu Liu; Jun Lu; Baiqu Huang
Journal: Cancer Res Date: 2012-07-11 Impact factor: 12.701

3. Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer.

Authors: Sandra D Castillo; Ander Matheu; Niccolo Mariani; Julian Carretero; Fernando Lopez-Rios; Robin Lovell-Badge; Montse Sanchez-Cespedes
Journal: Cancer Res Date: 2011-11-14 Impact factor: 12.701

Review 4. The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Authors: S J Vervoort; R van Boxtel; P J Coffer
Journal: Oncogene Date: 2012-12-17 Impact factor: 9.867

5. Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma.

Authors: Biaoyang Lin; Anup Madan; Jae-Geun Yoon; Xuefeng Fang; Xiaowei Yan; Taek-Kyun Kim; Daehee Hwang; Leroy Hood; Gregory Foltz
Journal: PLoS One Date: 2010-04-19 Impact factor: 3.240

Review 6. Critical roles for SoxC transcription factors in development and cancer.

Authors: Alfredo I Penzo-Méndez
Journal: Int J Biochem Cell Biol Date: 2009-08-03 Impact factor: 5.085

7. CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4.

Authors: Mohd S Iqbal; Ken-ichiro Otsuyama; Karim Shamsasenjan; Hideki Asaoku; Michio M Kawano
Journal: Int J Hematol Date: 2010-01-05 Impact factor: 2.490

8. Endogenous human microRNAs that suppress breast cancer metastasis.

Authors: Sohail F Tavazoie; Claudio Alarcón; Thordur Oskarsson; David Padua; Qiongqing Wang; Paula D Bos; William L Gerald; Joan Massagué
Journal: Nature Date: 2008-01-10 Impact factor: 49.962

9. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4.

Authors: M W Schilham; M A Oosterwegel; P Moerer; J Ya; P A de Boer; M van de Wetering; S Verbeek; W H Lamers; A M Kruisbeek; A Cumano; H Clevers
Journal: Nature Date: 1996-04-25 Impact factor: 49.962

10. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

Authors: C L Andersen; L L Christensen; K Thorsen; T Schepeler; F B Sørensen; H W Verspaget; R Simon; M Kruhøffer; L A Aaltonen; S Laurberg; T F Ørntoft
Journal: Br J Cancer Date: 2009-01-20 Impact factor: 7.640

12 in total

1. Clinical significance of vasculogenic mimicry, vascular endothelial cadherin and SOX4 in patients with esophageal squamous cell carcinoma.

Authors: Yanzi Qin; Wenjun Zhao; Lili Cheng; Shiwu Wu; Qiong Wu; Jin Gao; Zhaonan Bian; Li Ma
Journal: Int J Clin Exp Pathol Date: 2019-07-01

2. SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo.

Authors: Chi-Neu Tsai; Shu-Chuan Yu; Chao-Wei Lee; Jong-Hwei Su Pang; Chun-Hsin Wu; Sey-En Lin; Yi-Hsiu Chung; Chia-Lung Tsai; Sen-Yung Hsieh; Ming-Chin Yu
Journal: Oncogene Date: 2020-05-13 Impact factor: 9.867

3. Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor.

Authors: Hamid Nickho; Vahid Younesi; Leili Aghebati-Maleki; Morteza Motallebnezhad; Jafar Majidi Zolbanin; Aliakbar Movassagh Pour; Mehdi Yousefi
Journal: Bioengineered Date: 2016-11-16 Impact factor: 3.269

4. Novel acetylation-related gene signatures for predicting the prognosis of patients with colorectal cancer.

Authors: Zhuang Jing; Feng Ziwang; Wu Yinhang; Zhou Yani; Chu Jian; Wu Jingwen; Han Shuwen
Journal: Hum Cell Date: 2022-05-23 Impact factor: 4.174

5. MicroRNA-539 inhibits colorectal cancer progression by directly targeting SOX4.

Authors: Jian Zhao; Jian Xu; Rui Zhang
Journal: Oncol Lett Date: 2018-06-04 Impact factor: 2.967

6. Propofol Suppresses Esophageal Squamous Cell Carcinoma Cell Migration and Invasion by Down-Regulation of Sex-Determining Region Y-box 4 (SOX4).

Authors: Chun-Li Zhou; Jing-Jing Li; Peng Ji
Journal: Med Sci Monit Date: 2017-01-24

7. lncRNA PCNAP1 predicts poor prognosis in breast cancer and promotes cancer metastasis via miR‑340‑5p‑dependent upregulation of SOX4.

Authors: Yang Yu; Yaning He; Yingbo Shao; Qi Chen; Hui Liu
Journal: Oncol Rep Date: 2020-07-20 Impact factor: 3.906