Xiao Nong Zou1, Dongmei Lin2, Ann Chao3, Xia Wan4, Qinfu Feng5, Junling Li6, Jie Yang7, Gong Huan Yang4, Ning Lv2. 1. National Office of Cancer Prevention and Control, Cancer Institute/Hospital, Chinese Academy of Medical Sciences Beijing, China. 2. Department of Pathology, National Cancer Center, Cancer Institute/Hospital, Chinese Academy of Medical Sciences Beijing, China. 3. Center for Global Health, National Cancer Institute Bethesda, Maryland, USA. 4. Institute of Basic Medicine, Chinese Academy of Medical Sciences Beijing, China. 5. Department of Radiation Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences Beijing, China. 6. Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences Beijing, China. 7. Office of Tobacco Control, Chinese Center for Disease Control and Prevention Beijing, China.
Abstract
BACKGROUND: The aim of the study was to characterize the histological and epidemiological features of lung cancer in Chinese women. METHODS: Demographic and histological information on female lung cancer cases identified during 1 January 2000 through 31 December 2012 from the Cancer Hospital of the Chinese Academy of Medical Sciences were collected. The International Classification of Diseases for Oncology system was used to classify the histological subtypes. Relative frequencies (RF) were estimated for major histological subtypes and compared by the years of diagnosis and birth, and among residential areas. Statistical differences were tested for RFs in the time periods with a trend test and with Pearson Chi square tests for distribution. RESULTS: Of 7070 female Chinese lung cancer cases, the major histological subtypes were adenocarcinoma (ADC) 65.79%; squamous cell carcinoma (SCC) 10.21%; small cell cancer 8.12%; large cell carcinoma, 2.79%; and adeno-squamous carcinoma (ASC), 2.19%. ADC increased, with RFs from 46.72% in the cases identified in 2000-2002 to 76.49% in 2011-2012 (Z = 16.998, P < 0.0001); SCC decreased from 15.69% to 5.97% (Z = -8.750, P < 0.0001). Compared to the cases identified in 2000-2006, the age-adjusted RFs of ADC in 2007-2012 consistently increased in all study areas. CONCLUSION: The significant increase of ADC of the lung in Chinese women suggests that a persistently strong exposure to potential carcinogens in the Chinese population should be further and fully investigated.
BACKGROUND: The aim of the study was to characterize the histological and epidemiological features of lung cancer in Chinese women. METHODS: Demographic and histological information on female lung cancer cases identified during 1 January 2000 through 31 December 2012 from the Cancer Hospital of the Chinese Academy of Medical Sciences were collected. The International Classification of Diseases for Oncology system was used to classify the histological subtypes. Relative frequencies (RF) were estimated for major histological subtypes and compared by the years of diagnosis and birth, and among residential areas. Statistical differences were tested for RFs in the time periods with a trend test and with Pearson Chi square tests for distribution. RESULTS: Of 7070 female Chinese lung cancer cases, the major histological subtypes were adenocarcinoma (ADC) 65.79%; squamous cell carcinoma (SCC) 10.21%; small cell cancer 8.12%; large cell carcinoma, 2.79%; and adeno-squamous carcinoma (ASC), 2.19%. ADC increased, with RFs from 46.72% in the cases identified in 2000-2002 to 76.49% in 2011-2012 (Z = 16.998, P < 0.0001); SCC decreased from 15.69% to 5.97% (Z = -8.750, P < 0.0001). Compared to the cases identified in 2000-2006, the age-adjusted RFs of ADC in 2007-2012 consistently increased in all study areas. CONCLUSION: The significant increase of ADC of the lung in Chinese women suggests that a persistently strong exposure to potential carcinogens in the Chinese population should be further and fully investigated.
Entities:
Keywords:
Chinese; epidemiology; female; histology; lung cancer
Authors: Gong-Huan Yang; Qiang Li; Cong-Xiao Wang; Jason Hsia; Yan Yang; Lin Xiao; Jie Yang; Lu-Hua Zhao; Jian Zhang; Li Xie Journal: Biomed Environ Sci Date: 2010-12 Impact factor: 3.118