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Literature DB >> 267668

Virulence factors of Francisella tularensis.

Abstract

The mechanism causing viable Francisella tularensis to lose virulence in aerosols has been investigated. Fully virulent organisms were found to be encapsulated and avirulent organisms from aged aerosols, decapsulated. Capsules were also removed by suspension of F. tularensis in hypertonic sodium chloride. The resulting naked, but viable, organisms were predominantly avirulent for guinea-pigs challenged intraperitoneally. Capsular material and cell walls were found to contain large amounts of lipid, about 50 and 70% (w/w) respectively, and to differ in lipid and sugar composition. Isolated capsular material was not found to contain a lethal toxin for mice or guinea-pigs, or to induce an immunological response in these animals to fully virulent F. tularensis.

Entities: Chemical Disease Species

Mesh：

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Year: 1977 PMID： 267668 PMCID： PMC2129918 DOI： 10.1017/s0022172400052840

Source DB: PubMed Journal: J Hyg (Lond) ISSN： 0022-1724

25 in total

1. Studies on tularemia. I. The relation between certain pathogenic and immunogenic properties of variants of Pasteurella tularensis.

Authors: M D MOODY; C M DOWNS
Journal: J Bacteriol Date: 1955-09 Impact factor: 3.490

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Authors: C L LARSON; J F BELL; C R OWEN
Journal: J Immunol Date: 1954-10 Impact factor: 5.422

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Authors: D Stefanye; H B Tresselt; L Spero
Journal: J Bacteriol Date: 1961-03 Impact factor: 3.490

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Authors: W Hesselbrock; L Foshay
Journal: J Bacteriol Date: 1945-03 Impact factor: 3.490

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Authors: H T Eigelsbach; L A Chambers; L L Coriell
Journal: J Bacteriol Date: 1946-08 Impact factor: 3.490

6. Study of the microstructure of the two geographic races of the tularaemia bacterium in strains with different degrees of virulence.

Authors: I B Pavlova; I S Meshchekyakova; O S Emelyanova
Journal: J Hyg Epidemiol Microbiol Immunol Date: 1967

7. A simple method for the quantitation of submicrogram amounts of bacterial endotoxin.

Authors: R E Pieroni; E J Broderick; A Bundeally; L Levine
Journal: Proc Soc Exp Biol Med Date: 1970-03

8. Fatty acids of extractable and bound lipids of Rhodomicrobium vannielii.

Authors: C E Park; L R Berger
Journal: J Bacteriol Date: 1967-01 Impact factor: 3.490

9. Permeability of Serratia marcescens to some inorganic salts.

Authors: L Zimmerman
Journal: J Bacteriol Date: 1969-02 Impact factor: 3.490

10. In vitro interactions between rabbit alveolar macrophages and Pasteurella tularensis.

Authors: J E Nutter; Q N Myrvik
Journal: J Bacteriol Date: 1966-09 Impact factor: 3.490

48 in total

1. Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.

Authors: Stephen R Lindemann; Kaitian Peng; Matthew E Long; Jason R Hunt; Michael A Apicella; Denise M Monack; Lee-Ann H Allen; Bradley D Jones
Journal: Infect Immun Date: 2010-11-15 Impact factor: 3.441

2. A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge.

Authors: Qingmei Jia; Bai-Yu Lee; Richard Bowen; Barbara Jane Dillon; Susan M Som; Marcus A Horwitz
Journal: Infect Immun Date: 2010-07-19 Impact factor: 3.441

3. Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.

Authors: Grant S Schulert; Lee-Ann H Allen
Journal: J Leukoc Biol Date: 2006-06-30 Impact factor: 4.962

4. Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia.

Authors: Jed A Rasmussen; Deborah M B Post; Bradford W Gibson; Stephen R Lindemann; Michael A Apicella; David K Meyerholz; Bradley D Jones
Journal: Infect Immun Date: 2014-01-22 Impact factor: 3.441

5. Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.

Authors: Zhaohua Lu; Marly I Roche; Julia H Hui; Berkay Unal; Philip L Felgner; Sunita Gulati; Guillermo Madico; Jacqueline Sharon
Journal: Immunol Lett Date: 2007-08-08 Impact factor: 3.685

6. Fatty acid distribution in the phospholipids of Francisella tularensis.

Authors: R Anderson; A R Bhatti
Journal: Lipids Date: 1986-10 Impact factor: 1.880

7. Novel modification of lipid A of Francisella tularensis.

Authors: Nancy J Phillips; Birgit Schilling; Molly K McLendon; Michael A Apicella; Bradford W Gibson
Journal: Infect Immun Date: 2004-09 Impact factor: 3.441

8. Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis.

Authors: Michael A Apicella; Deborah M B Post; Andrew C Fowler; Bradley D Jones; Jed A Rasmussen; Jason R Hunt; Sayaka Imagawa; Biswa Choudhury; Thomas J Inzana; Tamara M Maier; Dara W Frank; Thomas C Zahrt; Kathryn Chaloner; Michael P Jennings; Molly K McLendon; Bradford W Gibson
Journal: PLoS One Date: 2010-07-06 Impact factor: 3.240

Review 9. Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.

Authors: Roger D Pechous; Travis R McCarthy; Thomas C Zahrt
Journal: Microbiol Mol Biol Rev Date: 2009-12 Impact factor: 11.056

10. Production and characterization of monoclonal antibodies directed against the lipopolysaccharide of Francisella tularensis.

Authors: M J Fulop; T Webber; R J Manchee; D C Kelly
Journal: J Clin Microbiol Date: 1991-07 Impact factor: 5.948