Literature DB >> 19946137

Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.

Roger D Pechous1, Travis R McCarthy, Thomas C Zahrt.   

Abstract

Francisella tularensis is a facultative intracellular gram-negative pathogen and the etiological agent of the zoonotic disease tularemia. Recent advances in the field of Francisella genetics have led to a rapid increase in both the generation and subsequent characterization of mutant strains exhibiting altered growth and/or virulence characteristics within various model systems of infection. In this review, we summarize the major properties of several Francisella species, including F. tularensis and F. novicida, and provide an up-to-date synopsis of the genes necessary for pathogenesis by these organisms and the determinants that are currently being targeted for vaccine development.

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Year:  2009        PMID： 19946137      PMCID： PMC2786580          DOI： 10.1128/MMBR.00028-09

Source DB:  PubMed          Journal:  Microbiol Mol Biol Rev        ISSN： 1092-2172            Impact factor:   11.056


  213 in total

1.  An outbreak of primary pneumonic tularemia on Martha's Vineyard.

Authors:  K A Feldman; R E Enscore; S L Lathrop; B T Matyas; M McGuill; M E Schriefer; D Stiles-Enos; D T Dennis; L R Petersen; E B Hayes
Journal:  N Engl J Med       Date:  2001-11-29       Impact factor: 91.245

2.  Low dose aerosol infection of mice with virulent type A Francisella tularensis induces severe thymus atrophy and CD4+CD8+ thymocyte depletion.

Authors:  Wangxue Chen; Rhonda Kuolee; John W Austin; Hua Shen; Yanming Che; J Wayne Conlan
Journal:  Microb Pathog       Date:  2005-10-28       Impact factor: 3.738

3.  Subunits of RNA polymerase in function and structure. IX. Regulation of RNA polymerase activity by stringent starvation protein (SSP).

Authors:  A Ishihama; T Saitoh
Journal:  J Mol Biol       Date:  1979-04-25       Impact factor: 5.469

4.  Construction of a shuttle vector for use in Francisella tularensis.

Authors:  A Norqvist; K Kuoppa; G Sandström
Journal:  FEMS Immunol Med Microbiol       Date:  1996-03

5.  The respiratory burst-inhibiting acid phosphatase AcpA is not essential for the intramacrophage growth or virulence of Francisella novicida.

Authors:  G S Baron; T J Reilly; F E Nano
Journal:  FEMS Microbiol Lett       Date:  1999-07-01       Impact factor: 2.742

Review 6.  Tularaemia.

Authors:  A Tärnvik; L Berglund
Journal:  Eur Respir J       Date:  2003-02       Impact factor: 16.671

7.  fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis Schu S4.

Authors:  Girija Ramakrishnan; Alexis Meeker; Bojan Dragulev
Journal:  J Bacteriol       Date:  2008-06-06       Impact factor: 3.490

8.  Passive protection of mice against lethal Francisella tularensis (live tularemia vaccine strain) infection by the sera of human recipients of the live tularemia vaccine.

Authors:  J J Drabick; R B Narayanan; J C Williams; J W Leduc; C A Nacy
Journal:  Am J Med Sci       Date:  1994-08       Impact factor: 2.378

9.  Immunospecific T-lymphocyte stimulation by membrane proteins from Francisella tularensis.

Authors:  G Sandström; A Tärnvik; H Wolf-Watz
Journal:  J Clin Microbiol       Date:  1987-04       Impact factor: 5.948

10.  Genetic dissection of the Francisella novicida restriction barrier.

Authors:  Larry A Gallagher; Matthew McKevitt; Elizabeth R Ramage; Colin Manoil
Journal:  J Bacteriol       Date:  2008-10-03       Impact factor: 3.490
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  65 in total

1.  Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis.

Authors:  Girija Ramakrishnan; Bhaswati Sen; Richard Johnson
Journal:  J Biol Chem       Date:  2012-06-01       Impact factor: 5.157

2.  Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

Authors:  Max Tze-Han Huang; Brittany L Mortensen; Debra J Taxman; Robin R Craven; Sharon Taft-Benz; Todd M Kijek; James R Fuller; Beckley K Davis; Irving Coy Allen; Willie June Brickey; Denis Gris; Haitao Wen; Thomas H Kawula; Jenny Pan-Yun Ting
Journal:  J Immunol       Date:  2010-10-04       Impact factor: 5.422

3.  Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies.

Authors:  Linxiao Chen; Jenny L Valentine; Chung-Jr Huang; Christine E Endicott; Tyler D Moeller; Jed A Rasmussen; Joshua R Fletcher; Joseph M Boll; Joseph A Rosenthal; Justyna Dobruchowska; Zhirui Wang; Christian Heiss; Parastoo Azadi; David Putnam; M Stephen Trent; Bradley D Jones; Matthew P DeLisa
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-06       Impact factor: 11.205

4.  Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis.

Authors:  Ekaterina V Filippova; Leigh A Weston; Misty L Kuhn; Brett Geissler; Alexandra M Gehring; Nicola Armoush; Chinessa T Adkins; George Minasov; Ievgeniia Dubrovska; Ludmilla Shuvalova; James R Winsor; Luke D Lavis; Karla J F Satchell; Daniel P Becker; Wayne F Anderson; R Jeremy Johnson
Journal:  J Biol Chem       Date:  2013-02-19       Impact factor: 5.157

5.  Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis.

Authors:  Rexford Asare; Yousef Abu Kwaik
Journal:  Environ Microbiol       Date:  2010-05-07       Impact factor: 5.491

6.  Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo.

Authors:  Joseph Horzempa; Dawn M O'Dee; Robert M Q Shanks; Gerard J Nau
Journal:  Infect Immun       Date:  2010-04-12       Impact factor: 3.441

Review 7.  Tularemia vaccines.

Authors:  Daniela Putzova; Iva Senitkova; Jiri Stulik
Journal:  Folia Microbiol (Praha)       Date:  2016-05-19       Impact factor: 2.099

8.  PanG, a new ketopantoate reductase involved in pantothenate synthesis.

Authors:  Cheryl N Miller; Eric D LoVullo; Todd M Kijek; James R Fuller; Jason C Brunton; Shaun P Steele; Sharon A Taft-Benz; Anthony R Richardson; Thomas H Kawula
Journal:  J Bacteriol       Date:  2012-12-14       Impact factor: 3.490

9.  Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.

Authors:  Lydia M Barrigan; Shraddha Tuladhar; Jason C Brunton; Matthew D Woolard; Ching-ju Chen; Divey Saini; Richard Frothingham; Gregory D Sempowski; Thomas H Kawula; Jeffrey A Frelinger
Journal:  Infect Immun       Date:  2013-03-25       Impact factor: 3.441

10.  Francisella tularensis type B ΔdsbA mutant protects against type A strain and induces strong inflammatory cytokine and Th1-like antibody response in vivo.

Authors:  Adela Straskova; Petra Spidlova; Sherry Mou; Patricia Worsham; Daniela Putzova; Ivona Pavkova; Jiri Stulik
Journal:  Pathog Dis       Date:  2015-08-06       Impact factor: 3.166
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