Literature DB >> 2676664

The cell biology of the insulin receptor.

J L Carpentier1.   

Abstract

Following initial binding to specific cell surface receptors insulin is internalized in target cells. The fate of the internalized insulin-receptor complexes and how the processes involved are regulated is reviewed. The implications of these events in the effects of insulin on its target cells and in the physiopathology of diabetes and insulin resistance states are also considered.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2676664     DOI： 10.1007/bf00274248

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  76 in total

1.  Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

Authors:  J L Carpentier; P Gorden; P Freychet; A Le Cam; L Orci
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

2.  Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits.

Authors:  J A Hedo; I A Simpson
Journal:  J Biol Chem       Date:  1984-09-10       Impact factor: 5.157

3.  Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes.

Authors:  P Gorden; J L Carpentier; P Freychet; A LeCam; L Orci
Journal:  Science       Date:  1978-05-19       Impact factor: 47.728

Review 4.  Membrane recycling by coated vesicles.

Authors:  B M Pearse; M S Bretscher
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

5.  Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

Authors:  P Gorden; J L Carpentier; S Cohen; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

6.  Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

Authors:  M Fehlmann; J L Carpentier; E Van Obberghen; P Freychet; P Thamm; D Saunders; D Brandenburg; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

7.  Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles.

Authors:  J Y Fan; J L Carpentier; P Gorden; E Van Obberghen; N M Blackett; C Grunfeld; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

8.  Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

Authors:  M Kasuga; Y Fujita-Yamaguchi; D L Blithe; C R Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

9.  Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.

Authors:  M Fehlmann; J L Carpentier; A Le Cam; P Thamm; D Saunders; D Brandenburg; L Orci; P Freychet
Journal:  J Cell Biol       Date:  1982-04       Impact factor: 10.539

10.  Detection of surface-bound ligands by freeze-fracture autoradiography.

Authors:  J L Carpentier; D Brown; B Iacopetta; L Orci
Journal:  J Cell Biol       Date:  1985-09       Impact factor: 10.539
View more
  11 in total

Review 1.  Diabetes mellitus.

Authors:  A B Johnson; R Taylor
Journal:  Postgrad Med J       Date:  1990-12       Impact factor: 2.401

2.  Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.

Authors:  J L Carpentier; J P Paccaud; P Gorden; W J Rutter; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.

Authors:  M Foti; J L Carpentier; C Aiken; D Trono; D P Lew; K H Krause
Journal:  Mol Biol Cell       Date:  1997-07       Impact factor: 4.138

Review 4.  The regulation of glucose transport in insulin-sensitive cells.

Authors:  H G Joost; T M Weber
Journal:  Diabetologia       Date:  1989-12       Impact factor: 10.122

5.  Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant.

Authors:  D C Thurmond; J E Pessin
Journal:  EMBO J       Date:  2000-07-17       Impact factor: 11.598

6.  Rapid effects of insulin on cyclic GMP location in an intact protozoan.

Authors:  L Kohidai; J Barsony; J Roth; S J Marx
Journal:  Experientia       Date:  1992-05-15

7.  Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

Authors:  Rodrigo A Fuentealba; Qiang Liu; Takahisa Kanekiyo; Juan Zhang; Guojun Bu
Journal:  J Biol Chem       Date:  2009-10-08       Impact factor: 5.157

8.  Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomes.

Authors:  K Haraguchi; M Rodbell
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

Review 9.  Insulin receptor internalization: molecular mechanisms and physiopathological implications.

Authors:  J L Carpentier
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

Review 10.  Robert Feulgen Prize Lecture 1993. The journey of the insulin receptor into the cell: from cellular biology to pathophysiology.

Authors:  J L Carpentier
Journal:  Histochemistry       Date:  1993-09
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.