Literature DB >> 644321

Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes.

P Gorden, J L Carpentier, P Freychet, A LeCam, L Orci.   

Abstract

Insulin labeled with iodine-125 binds to receptors on isolated rat hepatocytes. At low temperatures initial binding is restricted to the plasma membrane as detected by direct quantitative autoradiographic analysis with the electron microscope. With increasing time and temperature of incubation there is a systematic and progressive translocation of autoradiographic grains to a highly limited area of the cell periphery representing no more than 15% of the radius of the cell.

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Year:  1978        PMID： 644321     DOI： 10.1126/science.644321

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  46 in total

1.  Polypeptide hormones inside cells.

Authors: 
Journal:  Br Med J       Date:  1979-03-24

Review 2.  Hepatic Insulin Clearance: Mechanism and Physiology.

Authors:  Sonia M Najjar; Germán Perdomo
Journal:  Physiology (Bethesda)       Date:  2019-05-01

3.  In vivo imaging of insulin receptors in monkeys using 18F-labeled insulin and positron emission tomography.

Authors:  R C Eastman; R E Carson; K A Jacobson; Y Shai; M A Channing; B B Dunn; J D Bacher; E Baas; E Jones; K L Kirk
Journal:  Diabetes       Date:  1992-07       Impact factor: 9.461

4.  Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells.

Authors:  M Amherdt; Y C Patel; L Orci
Journal:  J Clin Invest       Date:  1989-08       Impact factor: 14.808

5.  Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.

Authors:  J M Backer; C R Kahn; M F White
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

6.  Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

Authors:  J L Carpentier; P Gorden; P Freychet; A Le Cam; L Orci
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

7.  Relationship of binding to internatlization of 125I-insulin in isolated rat hepatocytes.

Authors:  J L Carpentier; P Gorden; P Freychet; A LeCam; L Orci
Journal:  Diabetologia       Date:  1979-12       Impact factor: 10.122

8.  Intracellular localization of 125I-labeled insulin in hepatocytes from intact rat liver.

Authors:  J L Carpentier; P Gorden; P Barazzone; P Freychet; A Le Cam; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

9.  Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

Authors:  P Gorden; J L Carpentier; S Cohen; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

10.  Effect of glucagon on digestive enzyme synthesis, transport and secretion in mouse pancreatic acinar cells.

Authors:  M Singh
Journal:  J Physiol       Date:  1980-09       Impact factor: 5.182
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