Na Zheng1,2, Xian Min Xiao1, Kui Ran Dong1, Lian Chen3, Yang Yang Ma3, Kai Li4. 1. Department of Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, China. 2. Department of Pediatrics Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, China. 3. Department of Pathology, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, China. 4. Department of Surgery, Children's Hospital of Fudan University, Wanyuan Road 399, Minhang District, Shanghai, China. likai2727@163.com.
Abstract
PURPOSE: Primary gastric tumors in infants and children are rare, and their diagnosis and treatment have not been standardized to date. The objective of the present retrospective study was to analyze the clinical characteristics of these tumors and explore possible improvements in their diagnosis and treatment. METHODS: The study included 15 children with a diagnosis of primary gastric tumor confirmed by pathology. Clinical manifestations, diagnostic methods and treatment were analyzed retrospectively, and postoperative conditions were assessed in follow-up evaluations. RESULTS: There were nine boys and six girls aged 8 months to 13 years. The main presenting symptoms were abdominal pain, melena, fever of undetermined origin and pallor. Children were assessed by ultrasound, CT and upper gastrointestinal barium meal or gastroscopy and showed abdominal blockage or polypoid space-occupying lesions. All patients underwent surgery as initial treatment, and four patients received postoperative chemotherapy. During the follow-up period from 3 to 92 months, four cases were lost, one patient died of metastatic disease, two patients showed recurrence, and the remaining patients were alive without recurrence or progression. CONCLUSIONS: Owing to the atypical and often asymptomatic presentation of primary gastric tumors, careful evaluation using imaging modalities is critical in suspicious cases. Most primary gastric tumors in infants and children are benign or borderline. The prognosis, except in gastric carcinoma, is excellent with close follow-up when complete resection is achieved.
PURPOSE:Primary gastric tumors in infants and children are rare, and their diagnosis and treatment have not been standardized to date. The objective of the present retrospective study was to analyze the clinical characteristics of these tumors and explore possible improvements in their diagnosis and treatment. METHODS: The study included 15 children with a diagnosis of primary gastric tumor confirmed by pathology. Clinical manifestations, diagnostic methods and treatment were analyzed retrospectively, and postoperative conditions were assessed in follow-up evaluations. RESULTS: There were nine boys and six girls aged 8 months to 13 years. The main presenting symptoms were abdominal pain, melena, fever of undetermined origin and pallor. Children were assessed by ultrasound, CT and upper gastrointestinal barium meal or gastroscopy and showed abdominal blockage or polypoid space-occupying lesions. All patients underwent surgery as initial treatment, and four patients received postoperative chemotherapy. During the follow-up period from 3 to 92 months, four cases were lost, one patient died of metastatic disease, two patients showed recurrence, and the remaining patients were alive without recurrence or progression. CONCLUSIONS: Owing to the atypical and often asymptomatic presentation of primary gastric tumors, careful evaluation using imaging modalities is critical in suspicious cases. Most primary gastric tumors in infants and children are benign or borderline. The prognosis, except in gastric carcinoma, is excellent with close follow-up when complete resection is achieved.
Authors: Dong Hoon Shin; Jung Hee Lee; Hyun Jeong Kang; Kyung Un Choi; Jee Yeon Kim; Do Youn Park; Chang Hun Lee; Mee Young Sol; Jae Hong Park; Hae Young Kim; Elizabeth Montgomery Journal: J Clin Pathol Date: 2010-03 Impact factor: 3.411
Authors: Matthew T Harting; Martin L Blakely; Cynthia E Herzog; Kevin P Lally; Jaffer A Ajani; Richard J Andrassy Journal: J Pediatr Surg Date: 2004-08 Impact factor: 2.545