W Jiang1, Y Huang2, N Han2, F He1, M Li1, Z Bian1, J Liu2, T Sun2, L Zhu1. 1. Department of Orthopedics, Nanjing Medical University, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Hangzhou, China. 2. Department of Orthopedics, General Hospital of Beijing Military Command, Beijing, China.
Abstract
STUDY DESIGN: Randomized experimental study. OBJECTIVES: To investigate the molecular mechanisms of quercetin in spinal cord injury (SCI) rats. SETTING: China. METHODS: One hundred female Sprague-Dawley rats were randomly assigned into four groups: sham group, SCI group, SCI+Vehicle (Veh) group, and the SCI+Quercetin (Que) group. The influences of quercetin on proinflammatory cytokine levels, histological changes and locomotion scale were estimated. RESULTS: SCI significantly promoted nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation and increased proinflammatory cytokine productions in the SCI group as compared with the sham group. Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels. Moreover, quercetin administration attenuated histopathology and promoted locomotion recovery. CONCLUSION: Quercetin can attenuate tissue damage and improve neurological function recovery, and the mechanism may be related to the inhibition of NLRP3 inflammasome activation.
STUDY DESIGN: Randomized experimental study. OBJECTIVES: To investigate the molecular mechanisms of quercetin in spinal cord injury (SCI) rats. SETTING: China. METHODS: One hundred female Sprague-Dawley rats were randomly assigned into four groups: sham group, SCI group, SCI+Vehicle (Veh) group, and the SCI+Quercetin (Que) group. The influences of quercetin on proinflammatory cytokine levels, histological changes and locomotion scale were estimated. RESULTS: SCI significantly promoted nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation and increased proinflammatory cytokine productions in the SCI group as compared with the sham group. Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels. Moreover, quercetin administration attenuated histopathology and promoted locomotion recovery. CONCLUSION:Quercetin can attenuate tissue damage and improve neurological function recovery, and the mechanism may be related to the inhibition of NLRP3 inflammasome activation.
Authors: Adam R Ferguson; Randolph N Christensen; John C Gensel; Brandon A Miller; Fang Sun; Eric C Beattie; Jacqueline C Bresnahan; Michael S Beattie Journal: J Neurosci Date: 2008-10-29 Impact factor: 6.167
Authors: Kenji W Ruiz-Miyazawa; Larissa Staurengo-Ferrari; Sandra S Mizokami; Talita P Domiciano; Fabiana T M C Vicentini; Doumit Camilios-Neto; Wander R Pavanelli; Phileno Pinge-Filho; Flávio A Amaral; Mauro M Teixeira; Rubia Casagrande; Waldiceu A Verri Journal: Inflammopharmacology Date: 2017-05-15 Impact factor: 4.473
Authors: Zhu Xingyu; Ma Peijie; Peng Dan; Wang Youg; Wang Daojun; Chen Xinzheng; Zhang Xijun; Song Yangrong Journal: Cancer Med Date: 2016-10-05 Impact factor: 4.452