PURPOSE: Recent data regarding trans fatty acids (TFAs) have implicated these lipids as particularly deleterious to human health, causing systemic inflammation, endothelial dysfunction and possibly inflammation in the central nervous system (CNS). We aimed to clarify the impact of partially hydrogenated soybean oil (PHSO) with different TFA concentrations on cerebrospinal fluid (CSF), serum and hepatic parameters in adult Wistar rats. METHODS: Wistar rats (n = 15/group) were fed either a normolipidic diet or a hyperlipidic diet for 90 days. The normolipidic and hyperlipidic diets had the same ingredients except for fat compositions, concentrations and calories. We used lard in the cis fatty acid group and PHSO in the trans fatty acid group. The intervention groups were as follows: (1) low lard (LL), (2) high lard (HL), (3) low partially hydrogenated soybean oil (LPHSO) and (4) high partially hydrogenated soybean oil (HPHSO). Body weight, lipid profiles and the inflammatory responses in the CSF, serum and liver tissue were analyzed. RESULTS: Surprisingly, with the PHSO diet we observed a worse metabolic response that was associated with oxidative stress in hepatic tissue as well as impaired serum and CSF fluid parameters at both PHSO concentrations. In many analyses, there were no significant differences between the LPHSO and HPHSO diets. CONCLUSIONS: Dietary supplementation with PHSO impaired inflammatory parameters in CSF and blood, induced insulin resistance, altered lipid profiles and caused hepatic damage. Overall, these findings suggest that fat composition is more important than the quantity of fat consumed in terms of cis and trans fatty acid diets.
PURPOSE: Recent data regarding trans fatty acids (TFAs) have implicated these lipids as particularly deleterious to human health, causing systemic inflammation, endothelial dysfunction and possibly inflammation in the central nervous system (CNS). We aimed to clarify the impact of partially hydrogenated soybean oil (PHSO) with different TFA concentrations on cerebrospinal fluid (CSF), serum and hepatic parameters in adult Wistar rats. METHODS:Wistar rats (n = 15/group) were fed either a normolipidic diet or a hyperlipidic diet for 90 days. The normolipidic and hyperlipidic diets had the same ingredients except for fat compositions, concentrations and calories. We used lard in the cis fatty acid group and PHSO in the trans fatty acid group. The intervention groups were as follows: (1) low lard (LL), (2) high lard (HL), (3) low partially hydrogenated soybean oil (LPHSO) and (4) high partially hydrogenated soybean oil (HPHSO). Body weight, lipid profiles and the inflammatory responses in the CSF, serum and liver tissue were analyzed. RESULTS: Surprisingly, with the PHSO diet we observed a worse metabolic response that was associated with oxidative stress in hepatic tissue as well as impaired serum and CSF fluid parameters at both PHSO concentrations. In many analyses, there were no significant differences between the LPHSO and HPHSO diets. CONCLUSIONS: Dietary supplementation with PHSO impaired inflammatory parameters in CSF and blood, induced insulin resistance, altered lipid profiles and caused hepatic damage. Overall, these findings suggest that fat composition is more important than the quantity of fat consumed in terms of cis and trans fatty acid diets.
Authors: John D Brunzell; Michael Davidson; Curt D Furberg; Ronald B Goldberg; Barbara V Howard; James H Stein; Joseph L Witztum Journal: J Am Coll Cardiol Date: 2008-04-15 Impact factor: 24.094
Authors: Martha Clare Morris; Denis A Evans; Julia L Bienias; Christine C Tangney; David A Bennett; Neelum Aggarwal; Julie Schneider; Robert S Wilson Journal: Arch Neurol Date: 2003-02
Authors: Matheus Augusto de Bittencourt Pasquali; Marcos Roberto de Oliveira; Marco Antônio De Bastiani; Ricardo Fagundes da Rocha; Carlos Eduardo Schnorr; Juciano Gasparotto; Daniel Pens Gelain; José Cláudio Fonseca Moreira Journal: Cell Biochem Funct Date: 2012-04 Impact factor: 3.685
Authors: Shreya S Shah; Gaurang B Shah; Satbeer D Singh; Priyanshi V Gohil; Kajal Chauhan; Khyati A Shah; Mehul Chorawala Journal: Indian J Pharmacol Date: 2011-05 Impact factor: 1.200
Authors: Alexandre Wullschleger; Viktoria Kapina; Nicolas Molnarfi; Delphine S Courvoisier; Jörg D Seebach; Marie-Laure Santiago-Raber; Denis F Hochstrasser; Patrice H Lalive Journal: PLoS One Date: 2013-08-27 Impact factor: 3.240
Authors: Boris Klementiev; Shizhong Li; Irina Korshunova; Oksana Dmytriyeva; Stanislava Pankratova; Peter S Walmod; Laura K Kjær; Mattias S Dahllöf; Morten Lundh; Dan P Christensen; Thomas Mandrup-Poulsen; Elisabeth Bock; Vladimir Berezin Journal: J Neuroinflammation Date: 2014-02-03 Impact factor: 8.322
Authors: Ines C M Simoes; Justyna Janikiewicz; Judith Bauer; Agnieszka Karkucinska-Wieckowska; Piotr Kalinowski; Agnieszka Dobrzyń; Andrzej Wolski; Maciej Pronicki; Krzysztof Zieniewicz; Paweł Dobrzyń; Marcin Krawczyk; Hans Zischka; Mariusz R Wieckowski; Yaiza Potes Journal: Nutrients Date: 2019-11-24 Impact factor: 5.717
Authors: Larissa de Brito Medeiros; Susana Paula Almeida Alves; Rui José Branquinho de Bessa; Juliana Késsia Barbosa Soares; Camila Neves Meireles Costa; Jailane de Souza Aquino; Gerlane Coelho Bernardo Guerra; Daline Fernandes de Souza Araújo; Lydiane Tavares Toscano; Alexandre Sérgio Silva; Adriano Francisco Alves; Mateus Lacerda Pereira Lemos; Wydemberg José de Araujo; Ariosvaldo Nunes de Medeiros; Celso José Bruno de Oliveira; Rita de Cassia Ramos do Egypto Queiroga Journal: Sci Rep Date: 2021-09-23 Impact factor: 4.379