| Literature DB >> 2675423 |
Abstract
In trypanosomes, a single transcription unit usually covers several protein-coding genes. The primary transcript is cut up by trans-splicing and polyadenylation machineries to generate individual mature mRNAs. All nuclear mRNAs acquire the same capped 39 nucleotide sequence at their 5' end as a consequence of the trans-splicing event. Trans splicing is used in the synthesis of some mRNAs in nematodes and chloroplasts. These unusual systems are clearly related to cis-splicing systems, but it remains an intriguing question whether they are merely exotic offshoots of cis splicing or archaic remnants of cis-splicing progenitors.Mesh:
Year: 1989 PMID: 2675423 PMCID: PMC7134362 DOI: 10.1016/0168-9525(89)90082-6
Source DB: PubMed Journal: Trends Genet ISSN: 0168-9525 Impact factor: 11.639