Literature DB >> 2675423

Trans splicing in trypanosomes--archaism or adaptation?

P W Laird.   

Abstract

In trypanosomes, a single transcription unit usually covers several protein-coding genes. The primary transcript is cut up by trans-splicing and polyadenylation machineries to generate individual mature mRNAs. All nuclear mRNAs acquire the same capped 39 nucleotide sequence at their 5' end as a consequence of the trans-splicing event. Trans splicing is used in the synthesis of some mRNAs in nematodes and chloroplasts. These unusual systems are clearly related to cis-splicing systems, but it remains an intriguing question whether they are merely exotic offshoots of cis splicing or archaic remnants of cis-splicing progenitors.

Mesh:

Year:  1989        PMID: 2675423      PMCID: PMC7134362          DOI: 10.1016/0168-9525(89)90082-6

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  29 in total

1.  Evidence for in vivo trans splicing of pre-mRNAs in tobacco chloroplasts.

Authors:  B Koller; H Fromm; E Galun; M Edelman
Journal:  Cell       Date:  1987-01-16       Impact factor: 41.582

2.  Discontinuous transcription and splicing in trypanosomes.

Authors:  L H Van der Ploeg
Journal:  Cell       Date:  1986-11-21       Impact factor: 41.582

3.  Controlled turnover and 3' trimming of the trans splicing precursor of Trypanosoma brucei.

Authors:  P W Laird; A L ten Asbroek; P Borst
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

4.  Trans splicing of mRNA precursors in vitro.

Authors:  M M Konarska; R A Padgett; P A Sharp
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

5.  Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site.

Authors:  A C Forster; R H Symons
Journal:  Cell       Date:  1987-07-03       Impact factor: 41.582

Review 6.  Discontinuous transcription and antigenic variation in trypanosomes.

Authors:  P Borst
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

7.  Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5' end.

Authors:  J C Boothroyd; G A Cross
Journal:  Gene       Date:  1982-12       Impact factor: 3.688

8.  The 35-nucleotide spliced leader sequence is common to all trypanosome messenger RNA's.

Authors:  J A Walder; P S Eder; D M Engman; S T Brentano; R Y Walder; D S Knutzon; D M Dorfman; J E Donelson
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

9.  Trypanosome mRNAs have unusual "cap 4" structures acquired by addition of a spliced leader.

Authors:  K L Perry; K P Watkins; N Agabian
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

10.  Physical identification of branched intron side-products of splicing in Trypanosoma brucei.

Authors:  D Ralph; J Huang; L H Van der Ploeg
Journal:  EMBO J       Date:  1988-08       Impact factor: 11.598

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  28 in total

1.  Trypanosomatid transcription factors: waiting for Godot.

Authors:  Scott M Landfear
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-30       Impact factor: 11.205

2.  Protein kinase involved in flagellar-length control.

Authors:  Martin Wiese; Daniela Kuhn; Christoph G Grünfelder
Journal:  Eukaryot Cell       Date:  2003-08

3.  Domain structure of U2 and U4/U6 small nuclear ribonucleoprotein particles from Trypanosoma brucei: identification of trans-spliceosomal specific RNA-protein interactions.

Authors:  A Günzl; M Cross; A Bindereif
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

4.  Trans-splicing mutants of Chlamydomonas reinhardtii.

Authors:  M Goldschmidt-Clermont; J Girard-Bascou; Y Choquet; J D Rochaix
Journal:  Mol Gen Genet       Date:  1990-09

5.  The promoter for the procyclic acidic repetitive protein (PARP) genes of Trypanosoma brucei shares features with RNA polymerase I promoters.

Authors:  S D Brown; J Huang; L H Van der Ploeg
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

6.  Trans splicing in trypanosomes requires methylation of the 5' end of the spliced leader RNA.

Authors:  E Ullu; C Tschudi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

7.  Insertion of part of an intron into the 5' untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene.

Authors:  R Conrad; J Thomas; J Spieth; T Blumenthal
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

8.  Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype.

Authors:  L Miraglia; S Seiwert; A H Igel; M Ares
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

9.  In Euglena, spliced-leader RNA (SL-RNA) and 5S rRNA genes are tandemly repeated.

Authors:  M Keller; L H Tessier; R L Chan; J H Weil; P Imbault
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

10.  Different trans RNA splicing events in bloodstream and procyclic Trypanosoma brucei.

Authors:  Jared R Helm; Mary E Wilson; John E Donelson
Journal:  Mol Biochem Parasitol       Date:  2008-02-15       Impact factor: 1.759

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