| Literature DB >> 26753914 |
Eun-Young Kim1, Seung-Tae Kang1, Heejung Jung2,3, Chi Hoon Park2,3, Chang-Soo Yun2,3, Jong Yeon Hwang2,3, Byung Jin Byun2, Chong Ock Lee2, Hyoung Rae Kim2, Jae Du Ha2, Do Hyun Ryu1, Sung Yun Cho4,5.
Abstract
A series of pyridazin-3-one substituted with morpholino-pyrimidine derivatives was synthesized and evaluated as tyrosine kinase inhibitors against c-Met enzyme, and anti-proliferative activities of Hs746T human gastric cancer cell line. Most of compounds exhibited good biological activity, while compound 10, 12a, 14a displayed excellent c-Met enzyme inhibitory activities and Hs746T cell-based activities.Entities:
Keywords: Kinase inhibitor; Mesenchymal epithelial transition factor; Pyridazine derivatives; c-MET inhibitor
Mesh：
Substances：
Year: 2016 PMID： 26753914 DOI： 10.1007/s12272-015-0703-7
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946