| Literature DB >> 26753170 |
Aisha Harun1, Yevgeniy R Semenov1, Yuri Agrawal1.
Abstract
OBJECTIVE: Vestibular dysfunction increases with age and is associated with mobility difficulties and fall risk in older individuals. We evaluated whether vestibular function influences the ability to perform activities of daily living (ADLs).Entities:
Keywords: activities of daily living; disability; function; vestibular loss
Year: 2015 PMID: 26753170 PMCID: PMC4706363 DOI: 10.1177/2333721415607124
Source DB: PubMed Journal: Gerontol Geriatr Med ISSN: 2333-7214
Population Characteristics and ADL Impairment.[a]
| Characteristic | |||||
|---|---|---|---|---|---|
| Frequency (%) | Mean ADL impairment score[ | Number of ADL impairments[ | |||
| Demographic variables | |||||
| Age (decades) | <.0001 | <.0001 | |||
| 40-49 | 1,616 (32.2) | 0.7 (3.1) | 0.2 (1.0) | ||
| 50-59 | 1,157 (23.1) | 1.2 (3.9) | 0.3 (1.2) | ||
| 60-69 | 1,249 (24.9) | 3.0 (5.2) | 0.6 (1.5) | ||
| ≥70 | 995 (19.8) | 3.7 (5.5) | 0.7 (1.7) | ||
| Gender, | .004 | .001 | |||
| Female | 2,493 (49.7) | 2.4 (5.0) | 0.5 (1.5) | ||
| Male | 2,524 (50.3) | 1.6 (4.1) | 0.3 (1.2) | ||
| Race/ethnicity, | .071 | .063 | |||
| White | 2,754 (54.9) | 2.1 (4.5) | 0.4 (1.3) | ||
| Black | 916 (18.3) | 2.0 (4.7) | 0.4 (1.4) | ||
| Mexican American | 1,021 (20.4) | 1.8 (4.5) | 0.4 (1.3) | ||
| Other race | 326 (6.5) | 2.1 (5.1) | 0.5 (1.8) | ||
| Education, | <.0001 | <.0001 | |||
| <High school | 1,438 (28.7) | 3.0 (5.8) | 0.7 (1.8) | ||
| High school graduate | 1,222 (24.4) | 2.3 (4.8) | 0.5 (1.4) | ||
| >High school | 2,351 (46.9) | 1.3 (3.3) | 0.2 (0.9) | ||
| Health-related variables | |||||
| Vestibular dysfunction, | <.0001 | <.0001 | |||
| Yes | 2,006 (40.0) | 3.0 (5.3) | 0.6 (1.6) | ||
| No | 3,011 (60.0) | 1.4 (3.9) | 0.3 (1.2) | ||
| Smoking, number of pack-years (%) | .016 | .036 | |||
| Never | 2,399 (47.8) | 1.7 (4.3) | 0.4 (1.2) | ||
| <20 | 1,187 (23.7) | 1.9 (4.2) | 0.4 (1.2) | ||
| ≥20 | 1,171 (23.3) | 2.8 (5.4) | 0.6 (1.6) | ||
| Unknown | 260 (5.2) | 1.6 (4.4) | 0.4 (1.5) | ||
| Hypertension, | <.0001 | <.0001 | |||
| Yes | 2,504 (50.0) | 2.6 (5.0) | 0.6 (1.5) | ||
| No | 2,504 (50.0) | 1.4 (4.0) | 0.3 (1.2) | ||
| Diabetes, | .072 | .014 | |||
| Yes | 1,922 (39.1) | 2.2 (4.8) | 0.5 (1.4) | ||
| No | 3,000 (60.9) | 1.9 (4.4) | 0.4 (1.3) | ||
| Stroke, | <.0001 | <.0001 | |||
| Yes | 143 (2.9) | 5.3 (7.6) | 1.2 (2.4) | ||
| No | 4,867 (97.1) | 1.9 (4.4) | 0.4 (1.3) | ||
| PTA, better ear, dB ( | <.0001 | <.0001 | |||
| ≤25 dB | 1,367 (87.4) | 1.4 (4.0) | 0.3 (1.4) | ||
| >25 dB | 198 (12.7) | 2.2 (4.6) | 0.5 (1.3) | ||
| Visual acuity, /20 ( | <.0001 | <.0001 | |||
| ≤20/20 | 2,792 (56.8) | 1.5 (4.0) | 0.3 (1.1) | ||
| >20/20 | 2,122 (43.2) | 2.5 (5.0) | 0.5 (1.6) | ||
Note. ADLs = activities of daily living; PTA = pure-tone average; NHANES = National Health and Nutrition Examination Survey.
Using NHANES 1999-2004 with population-adjusted weights.
Index aggregated and scaled by summing performance on 19 ADLs. Responses to individual activities range from 1 (no impairment) to 4 (complete impairment). Data were rescaled by subtracting 19 from each observation to allow the index to have a minimum value of zero, ranging from 0 (no impairment) to 57 (complete impairment).
Total number of ADL impairments (0-19).
Hearing loss defined as pure-tone threshold average across 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz (whichever is lower between right and left ear).
Nonrefracted visual acuity defined as 20/20 (20), 20/30 (30), 20/40 (40), 20/50 (50), and 20/60 (60), 20/70 (70), 20/80 (80), 20/200 (200), 20/200+ (666) (whichever is lower between right and left eye).
Multivariable Regression Model of the Association of Vestibular Dysfunction With ADL Impairment Score and With Total Number of ADL Impairments.[a]
| Variable | ADL impairment score[ | Number of ADL impairments[ | ||
|---|---|---|---|---|
| β (95% CI) | β (95% CI) | |||
| Vestibular dysfunction | 0.75 [0.36, 1.14] | <.0001 | 0.21 [0.09, 0.33] | .001 |
| Age | 0.06 [0.05 0.08] | <.0001 | 0.01 [0.001, 0.01] | .018 |
| Female | 0.60 [0.40, 0.80] | <.0001 | 0.12 [0.06, 0.17] | <.0001 |
| Race/ethnicity | ||||
| White | Reference | Reference | ||
| Black | −0.04 [−0.38, 0.31] | .838 | −0.02 [−0.11, 0.07] | .708 |
| Mexican American | −0.68 [−1.10, −0.27] | .002 | −0.21 [−0.32, −0.09] | .001 |
| Other race | 0.25 [−0.47, 0.97] | .491 | 0.12 [−0.16, 0.40] | .383 |
| Education | ||||
| <High school | Reference | Reference | ||
| High school graduate | −1.00 [−1.66, −0.34] | .004 | −0.31 [−0.47, −0.14] | <.0001 |
| >High school | −1.70 [−2.19, −1.20] | <.0001 | −0.50 [−0.64, −0.36] | <.0001 |
| Smoking, number of pack-years | ||||
| Never | Reference | Reference | ||
| <20 | 0.20 [−0.13, 0.53] | .221 | 0.05 [−0.05, 0.15] | .287 |
| ≥20 | 0.67 [0.23, 1.11] | .004 | 0.21 [0.06, 0.36] | .008 |
| Unknown | −0.11 [−0.57, 0.34] | .611 | 0.003 [−0.14, 0.15] | .966 |
| Hypertension | 0.36 [0.10, 0.63] | .009 | 0.10 [0.02, 0.18] | .020 |
| Diabetes | 0.12 [−0.21, 0.44] | .467 | −0.02 [−0.08, 0.12] | .727 |
| Stroke | 1.89 [0.69, 3.08] | .003 | 0.49 [0.12, 0.87] | .010 |
| Visual acuity | 0.01 [0, 0.02] | .219 | 0.003 [0.002, 0.008] | .245 |
Note. ADLs = activities of daily living; CI = confidence interval; NHANES = National Health and Nutrition Examination Survey.
Using NHANES 1999 to 2004 with population-adjusted weights.
Linear regression model for continuous outcome of total ADL index score (0-57). Index aggregated and scaled by summing performance on 19 ADLs. Responses to individual activities range from 1 (no impairment) to 4 (complete impairment). Data were rescaled by subtracting 19 from each observation to allow the index to have a minimum value of 0, ranging from 0 (no impairment) to 57 (complete impairment).
Linear regression model for the continuous outcome of the total number of ADL impairments (0-19) adjusted for demographic variables and comorbidities.
Figure 1.Odds of ADL impairment associated with vestibular dysfunction.
Note. ADLs = activities of daily living.
Figure 2.Structural equation modeling and mediation analyses.
Note. Role of aging and sensory loss in ADL impairment. Vestibular dysfunction mediated 21.7% of the association between aging and ADL impairment. Hearing and vision loss mediated 8.9% and 0%, respectively, of the association between aging and ADL impairment. All models are adjusted for race, gender, education, smoking status, hypertension, diabetes, stroke, visual acuity, and hearing loss. The percent mediation of vestibular dysfunction is calculated based on the formula (A × B) / [(A × B) + C], where A × B is the indirect effect of aging on ADL impairment medication by vestibular function, and C is the direct effect of aging on ADL impairment. ADLs = activities of daily living.