Literature DB >> 2675314

Microcolumn separations and the analysis of single cells.

R T Kennedy1, M D Oates, B R Cooper, B Nickerson, J W Jorgenson.   

Abstract

Capillary zone electrophoresis and open tubular liquid chromatography are two examples of an emerging area of analytical instrumentation known as microcolumn separations. The high resolution and small sample requirements of these methods make them suitable for the quantitative, multicomponent chemical analysis of single cells. Appropriate instrumentation for the analysis of nanoliter and subnanoliter samples is discussed. Data from the analysis of individual neurons are presented, including amino acid and neurotransmitter content.

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Year:  1989        PMID： 2675314     DOI： 10.1126/science.2675314

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Chemical cytometry on a picoliter-scale integrated microfluidic chip.

Authors:  Hongkai Wu; Aaron Wheeler; Richard N Zare
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-24       Impact factor: 11.205

2.  Sampling techniques for single-cell electrophoresis.

Authors:  Christine Cecala; Jonathan V Sweedler
Journal:  Analyst       Date:  2012-01-30       Impact factor: 4.616

3.  Indium-tin oxide coated microfabricated device for the injection of a single cell into a fused silica capillary for chemical cytometry.

Authors:  Anna Boardman; Tim Chang; Albert Folch; Norman J Dovichi
Journal:  Anal Chem       Date:  2010-10-29       Impact factor: 6.986

Review 4.  Recent advances in capillary electrophoretic analysis of individual cells.

Authors:  Imee G Arcibal; Michael F Santillo; Andrew G Ewing
Journal:  Anal Bioanal Chem       Date:  2006-08-16       Impact factor: 4.142

5.  Coaxial flow system for chemical cytometry.

Authors:  Paul J Marc; Christopher E Sims; Nancy L Allbritton
Journal:  Anal Chem       Date:  2007-11-03       Impact factor: 6.986

6.  Effect of decreasing column inner diameter and use of off-line two-dimensional chromatography on metabolite detection in complex mixtures.

Authors:  James L Edwards; Rachel L Edwards; Kendra R Reid; Robert T Kennedy
Journal:  J Chromatogr A       Date:  2007-10-10       Impact factor: 4.759

7.  Secondary ion MS imaging to relatively quantify cholesterol in the membranes of individual cells from differentially treated populations.

Authors:  Sara G Ostrowski; Michael E Kurczy; Thomas P Roddy; Nicholas Winograd; Andrew G Ewing
Journal:  Anal Chem       Date:  2007-04-12       Impact factor: 6.986

8.  Identification of receptor ligands and receptor subtypes using antagonists in a capillary electrophoresis single-cell biosensor separation system.

Authors:  H A Fishman; O Orwar; R H Scheller; R N Zare
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop.

Authors:  J Bergquist; A Tarkowski; R Ekman; A Ewing
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics.

Authors:  Theodore Lapainis; Stanislav S Rubakhin; Jonathan V Sweedler
Journal:  Anal Chem       Date:  2009-07-15       Impact factor: 6.986
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