| Literature DB >> 26751997 |
Khalid Oumzil1,2, Michael A Ramin1,2, Cyril Lorenzato3, Audrey Hémadou3, Jeanny Laroche3, Marie Josée Jacobin-Valat3, Stephane Mornet4, Claude-Eric Roy1,2, Tina Kauss1,2, Karen Gaudin1,2, Gisèle Clofent-Sanchez3, Philippe Barthélémy1,2.
Abstract
Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.Entities:
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Year: 2016 PMID： 26751997 DOI： 10.1021/acs.bioconjchem.5b00590
Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774