Literature DB >> 2674680

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

L J van 't Veer1, B M Burgering, R Versteeg, A J Boot, D J Ruiter, S Osanto, P I Schrier, J L Bos.   

Abstract

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.

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Year:  1989        PMID： 2674680      PMCID： PMC362784          DOI： 10.1128/mcb.9.7.3114-3116.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  22 in total

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Journal:  J Mol Biol       Date:  1985-03-05       Impact factor: 5.469

Review 2.  Solar exposure in the etiology of cutaneous melanoma.

Authors:  A J Sober
Journal:  Photodermatol       Date:  1987-02

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Authors:  R A Padua; N C Barrass; G A Currie
Journal:  Mol Cell Biol       Date:  1985-03       Impact factor: 4.272

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Authors:  T B Fitzpatrick; A J Sober
Journal:  N Engl J Med       Date:  1985-09-26       Impact factor: 91.245

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Authors:  A P Albino; R Le Strange; A I Oliff; M E Furth; L J Old
Journal:  Nature       Date:  1984 Mar 1-7       Impact factor: 49.962

6.  Risk factors for cutaneous malignant melanoma: the Western Canada Melanoma Study.

Authors:  R P Gallagher; J M Elwood; G B Hill
Journal:  Recent Results Cancer Res       Date:  1986

7.  The causes of malignant melanoma: results from the West Australian Lions Melanoma Research Project.

Authors:  C D Holman; B K Armstrong; P J Heenan; J B Blackwell; F J Cumming; D R English; S Holland; G R Kelsall; L R Matz; I L Rouse
Journal:  Recent Results Cancer Res       Date:  1986

8.  A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides.

Authors:  M Verlaan-de Vries; M E Bogaard; H van den Elst; J H van Boom; A J van der Eb; J L Bos
Journal:  Gene       Date:  1986       Impact factor: 3.688

9.  Cutaneous melanoma in relation to intermittent and constant sun exposure--the Western Canada Melanoma Study.

Authors:  J M Elwood; R P Gallagher; G B Hill; J C Pearson
Journal:  Int J Cancer       Date:  1985-04-15       Impact factor: 7.396

10.  Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells.

Authors:  H C Hsia; J S Lebkowski; P M Leong; M P Calos; J H Miller
Journal:  J Mol Biol       Date:  1989-01-05       Impact factor: 5.469
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  63 in total

Review 1.  Delving into somatic variation in sporadic melanoma.

Authors:  Vijay Walia; Euphemia W Mu; Jimmy C Lin; Yardena Samuels
Journal:  Pigment Cell Melanoma Res       Date:  2012-02-13       Impact factor: 4.693

Review 2.  From genes to drugs: targeted strategies for melanoma.

Authors:  Keith T Flaherty; F Stephen Hodi; David E Fisher
Journal:  Nat Rev Cancer       Date:  2012-04-05       Impact factor: 60.716

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Authors:  Julie A Ellerhorst; Victoria R Greene; Suhendan Ekmekcioglu; Carla L Warneke; Marcella M Johnson; Carolyn P Cooke; Li-E Wang; Victor G Prieto; Jeffrey E Gershenwald; Qingyi Wei; Elizabeth A Grimm
Journal:  Clin Cancer Res       Date:  2010-10-25       Impact factor: 12.531

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Authors:  T Shioda; M H Fenner; K J Isselbacher
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

5.  Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.

Authors:  Yusuke Kito; Juncheng Bai; Naoe Goto; Hiroshi Okubo; Yoshihiro Adachi; Tomoko Nagayama; Tamotsu Takeuchi
Journal:  Int J Exp Pathol       Date:  2013-10-31       Impact factor: 1.925

6.  Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

Authors:  Christian Posch; Homayoun Moslehi; Luzviminda Feeney; Gary A Green; Anoosheh Ebaee; Valentin Feichtenschlager; Kim Chong; Lily Peng; Michelle T Dimon; Thomas Phillips; Adil I Daud; Timothy H McCalmont; Philip E LeBoit; Susana Ortiz-Urda
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-19       Impact factor: 11.205

7.  Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.

Authors:  Abdallah Sayyed-Ahmad; Priyanka Prakash; Alemayehu A Gorfe
Journal:  Proteins       Date:  2017-05-31

8.  Immunohistochemical examination of tumor-suppressor gene p53 product and pyrimidine dimer in solar keratosis.

Authors:  M Taguchi; S Watanabe; Y Sato; T Kameya; N Munakata; K Ishihara; P K Nakane; H Hisatome; S Ikeda
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

9.  Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site.

Authors:  Anton Platz; Suzanne Egyhazi; Ulrik Ringborg; Johan Hansson
Journal:  Mol Oncol       Date:  2007-12-28       Impact factor: 6.603

Review 10.  What are we learning from the cancer genome?

Authors:  Eric A Collisson; Raymond J Cho; Joe W Gray
Journal:  Nat Rev Clin Oncol       Date:  2012-09-11       Impact factor: 66.675
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