Ataç Çelik1, Mustafa Özçetin2, Ömer Ateş3, Fatih Altunkaş1, Kayıhan Karaman1, İlker Akar4, İlker İnce4, Murat Yalçın5, Metin Karayakalı1, Köksal Ceyhan1, Fatih Koç6. 1. Department of Cardiology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. 2. Department of Pediactics, Süleymaniye Obstetrics and Gynecology Training and Research Hospital, İstanbul, Turkey. 3. Department of Medical Biology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. 4. Department of Cardiovascular Surgery, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey. 5. Department of Cardiology, GATA Haydarpaşa Military Hospital, İstanbul, Turkey. 6. Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Abstract
BACKGROUND: Family history of premature atherosclerosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and Interleukin-6 (IL-6) has shown in previous studies. AIMS: The major aim of the study was to evaluate the CRP, eNOS, and IL-6 gene polymorphisms in a group of adolescents who have a parental history of early coronary artery disease (CAD). STUDY DESIGN: Case-control study. METHODS: Thirty-six volunteers with a father with obstructive CAD during the first four decades and 46 subjects with a father with normal coronary arteries documented with coronary angiography were included in the study. Polymerase chain reaction-restriction fragment length polymorphism techniques were used to analyze CRP, eNOS, and IL-6 polymorphisms. RESULTS: We did not find any differences between the two groups with regard to age, sex, body mass index, renal functions, systolic and diastolic blood pressures, lipid profile, and fasting glucose, hemoglobin, and high sensitivity CRP. A significant difference was only observed in IL-6-572 G/C genotype distribution and allele frequency between two groups (Pc=0.036 OR=3.48 CI (95%) 1.17-10.32). CONCLUSION: The present study showed a significant association between the IL-6-572 G/C gene polymorphism (presence of C allele) and adolescents with a parental history of premature CAD.
BACKGROUND: Family history of premature atherosclerosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and Interleukin-6 (IL-6) has shown in previous studies. AIMS: The major aim of the study was to evaluate the CRP, eNOS, and IL-6 gene polymorphisms in a group of adolescents who have a parental history of early coronary artery disease (CAD). STUDY DESIGN: Case-control study. METHODS: Thirty-six volunteers with a father with obstructive CAD during the first four decades and 46 subjects with a father with normal coronary arteries documented with coronary angiography were included in the study. Polymerase chain reaction-restriction fragment length polymorphism techniques were used to analyze CRP, eNOS, and IL-6 polymorphisms. RESULTS: We did not find any differences between the two groups with regard to age, sex, body mass index, renal functions, systolic and diastolic blood pressures, lipid profile, and fasting glucose, hemoglobin, and high sensitivity CRP. A significant difference was only observed in IL-6-572 G/C genotype distribution and allele frequency between two groups (Pc=0.036 OR=3.48 CI (95%) 1.17-10.32). CONCLUSION: The present study showed a significant association between the IL-6-572 G/C gene polymorphism (presence of C allele) and adolescents with a parental history of premature CAD.
Authors: Ahmet Ekmekçi; Mahmut Uluganyan; Barış Güngör; Neslihan Abacı; Kazım Serhan Ozcan; Gökhan Ertaş; Aycan Zencirci; Ahmet Yavuz Balcı; Sema Sırma Ekmekci; Nurten Sayar; Duran Ustek; Mehmet Eren Journal: Turk Kardiyol Dern Ars Date: 2014-01
Authors: D J Brull; Norma Serrano; F Zito; Lisa Jones; H E Montgomery; A Rumley; Pankaj Sharma; G D O Lowe; M J World; S E Humphries; A D Hingorani Journal: Arterioscler Thromb Vasc Biol Date: 2003-07-03 Impact factor: 8.311