Literature DB >> 26739910

Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward.

Nathan D Lawson1.   

Abstract

Gene editing in zebrafish has begun to reveal discordance between mutant phenotypes and those associated with knockdown via morpholino oligonucleotides (MOs). These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene function in zebrafish.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26739910     DOI： 10.1016/j.tcb.2015.11.005

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  16 in total

1.  Histone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation.

Authors:  Alexander A Akerberg; Astra Henner; Scott Stewart; Kryn Stankunas
Journal:  Dev Biol       Date:  2017-04-01       Impact factor: 3.582

Review 2.  LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.

Authors:  Philipp Gut; Sven Reischauer; Didier Y R Stainier; Rima Arnaout
Journal:  Physiol Rev       Date:  2017-07-01       Impact factor: 37.312

3.  Zebrafish behavior as a gateway to nervous system assembly and plasticity.

Authors:  Jessica C Nelson; Michael Granato
Journal:  Development       Date:  2022-05-12       Impact factor: 6.862

Review 4.  Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.

Authors:  Benjamin E Housden; Matthias Muhar; Matthew Gemberling; Charles A Gersbach; Didier Y R Stainier; Geraldine Seydoux; Stephanie E Mohr; Johannes Zuber; Norbert Perrimon
Journal:  Nat Rev Genet       Date:  2016-10-31       Impact factor: 53.242

Review 5.  Zebrafish as an Emerging Model Organism to Study Angiogenesis in Development and Regeneration.

Authors:  Myra N Chávez; Geraldine Aedo; Fernando A Fierro; Miguel L Allende; José T Egaña
Journal:  Front Physiol       Date:  2016-03-08       Impact factor: 4.566

6.  Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors.

Authors:  Marine Joris; Marie Schloesser; Denis Baurain; Marc Hanikenne; Marc Muller; Patrick Motte
Journal:  Nucleic Acids Res       Date:  2017-09-19       Impact factor: 16.971

7.  On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin.

Authors:  Richard Lyle Londraville; Jeremy W Prokop; Robert Joel Duff; Qin Liu; Matthew Tuttle
Journal:  Front Endocrinol (Lausanne)       Date:  2017-04-10       Impact factor: 5.555

8.  Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein.

Authors:  Tamar E Sztal; Emily A McKaige; Caitlin Williams; Avnika A Ruparelia; Robert J Bryson-Richardson
Journal:  PLoS Genet       Date:  2018-02-08       Impact factor: 5.917

9.  Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression.

Authors:  Rosa L Moreno; Kristina Williams; Kenneth L Jones; Angeles B Ribera
Journal:  PLoS One       Date:  2018-06-21       Impact factor: 3.240

10.  A gene trap transposon eliminates haematopoietic expression of zebrafish Gfi1aa, but does not interfere with haematopoiesis.

Authors:  Roshana Thambyrajah; Deniz Ucanok; Maryam Jalali; Yasmin Hough; Robert Neil Wilkinson; Kathryn McMahon; Chris Moore; Martin Gering
Journal:  Dev Biol       Date:  2016-07-16       Impact factor: 3.582
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