Igor A Sobenin1, Irina V Andrianova2, Konstantin Y Lakunin3, Vasilii P Karagodin4, Yuri V Bobryshev5, Alexander N Orekhov6. 1. Russian Cardiology Research and Production Complex, 121552 Moscow, Russia; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia. 2. Russian Cardiology Research and Production Complex, 121552 Moscow, Russia. 3. Institute for Atherosclerosis Research, Skolkovo Innovation Center, Skolkovo, 143025 Moscow Region, Russia. 4. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia. 5. Institute for Atherosclerosis Research, Skolkovo Innovation Center, Skolkovo, 143025 Moscow Region, Russia; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: y.bobryshev@unsw.edu.au. 6. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovation Center, Skolkovo, 143025 Moscow Region, Russia; Department of Biophysics, Biological Faculty, Moscow State University, Moscow 119991, Russia.
Abstract
BACKGROUND: Garlic (Allium sativum L.) is one of the most popular substances used to reduce various risks associated with cardiovascular disease. However, little is known on the direct effects of garlic on atherosclerosis. PURPOSE: In the present study we have examined the effect of per oral administration of the time-released garlic herbal preparation on serum atherogenicity and formation of intimal thickening after freeze injury in cholesterol-fed rabbits. METHODS: Group 1 rabbits maintained on the standard cholesterol-rich diet served as the control. Group 2 rabbits were fed the cholesterol-rich diet and treated with garlic preparation containing 300 mg garlic powder. RESULTS: Local thickening of the aortic media (i.e., the neointima formation) in the freeze injury zone was observed in all the rabbits. Regular garlic preparation therapy prevented the neointima formation and the accumulation of free and esterified cholesterol, triglycerides, phospholipids and collagen in the neointima, the effects being statistically significant. Garlic preparation also decreased serum lipid content by 1.5-fold and lowered atherogenic activity of blood serum (ability to induce lipid accumulation in cultured cells) induced by cholesterol-rich diet. CONCLUSION: The results obtained indicate that garlic preparation prevents the development of cholesterol-induced experimental atherosclerosis and possesses the direct anti-atherogenic activity.
BACKGROUND:Garlic (Allium sativum L.) is one of the most popular substances used to reduce various risks associated with cardiovascular disease. However, little is known on the direct effects of garlic on atherosclerosis. PURPOSE: In the present study we have examined the effect of per oral administration of the time-released garlic herbal preparation on serum atherogenicity and formation of intimal thickening after freeze injury in cholesterol-fed rabbits. METHODS: Group 1 rabbits maintained on the standard cholesterol-rich diet served as the control. Group 2 rabbits were fed the cholesterol-rich diet and treated with garlic preparation containing 300 mg garlic powder. RESULTS: Local thickening of the aortic media (i.e., the neointima formation) in the freeze injury zone was observed in all the rabbits. Regular garlic preparation therapy prevented the neointima formation and the accumulation of free and esterified cholesterol, triglycerides, phospholipids and collagen in the neointima, the effects being statistically significant. Garlic preparation also decreased serum lipid content by 1.5-fold and lowered atherogenic activity of blood serum (ability to induce lipid accumulation in cultured cells) induced by cholesterol-rich diet. CONCLUSION: The results obtained indicate that garlic preparation prevents the development of cholesterol-induced experimental atherosclerosis and possesses the direct anti-atherogenic activity.
Authors: Tatiana V Kirichenko; Vasily N Sukhorukov; Alexander M Markin; Nikita G Nikiforov; Ping-Yen Liu; Igor A Sobenin; Vadim V Tarasov; Alexander N Orekhov; Gjumrakch Aliev Journal: Front Pharmacol Date: 2020-04-08 Impact factor: 5.810
Authors: Attila Biró; Arnold Markovics; Mónika Éva Fazekas; Gábor Fidler; Gábor Szalóki; Melinda Paholcsek; János Lukács; László Stündl; Judit Remenyik Journal: Nutrients Date: 2020-06-05 Impact factor: 5.717