Literature DB >> 26739053

Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68.

Blaise Ndjamen1, Devashish S Joshi1, Scott E Fraser2, Pamela J Bjorkman3.   

Abstract

The human cytomegalovirus glycoprotein gp68 functions as an Fc receptor for host IgGs and can form antibody bipolar bridging (ABB) complexes in which gp68 binds the Fc region of an antigen-bound IgG. Here we show that gp68-mediated endocytosis transports ABB complexes into endosomes, after which the complex is routed to lysosomes, presumably for degradation. These results suggest gp68 contributes to evasion of IgG-mediated immune responses by mediating destruction of host IgG and viral antigens.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26739053      PMCID： PMC4810659          DOI： 10.1128/JVI.02855-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Direct evidence for antibody bipolar bridging on herpes simplex virus-infected cells.

Authors:  K E Van Vliet; L A De Graaf-Miltenburg; J Verhoef; J A Van Strijp
Journal:  Immunology       Date:  1992-09       Impact factor: 7.397

2.  A herpes simplex virus gD-YFP fusion glycoprotein is transported separately from viral capsids in neuronal axons.

Authors:  Aleksandra Snyder; Birgitte Bruun; Helena M Browne; David C Johnson
Journal:  J Virol       Date:  2007-05-23       Impact factor: 5.103

3.  Binding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus.

Authors:  Annika Antonsson; P J Hugo Johansson
Journal:  J Gen Virol       Date:  2001-05       Impact factor: 3.891

4.  A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G.

Authors:  I Frank; H M Friedman
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

5.  Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein.

Authors:  B N Lilley; H L Ploegh; R S Tirabassi
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

6.  Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity.

Authors:  G Dubin; E Socolof; I Frank; H M Friedman
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

Review 7.  CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity.

Authors:  Eugenia Corrales-Aguilar; Katja Hoffmann; Hartmut Hengel
Journal:  Semin Immunopathol       Date:  2014-10-07       Impact factor: 9.623

Review 8.  The interface of receptor trafficking and signalling.

Authors:  M J Clague; S Urbé
Journal:  J Cell Sci       Date:  2001-09       Impact factor: 5.285

9.  Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging.

Authors:  Elizabeth R Sprague; Chu Wang; David Baker; Pamela J Bjorkman
Journal:  PLoS Biol       Date:  2006-05-02       Impact factor: 8.029

10.  Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

Authors:  C E Futter; A Pearse; L J Hewlett; C R Hopkins
Journal:  J Cell Biol       Date:  1996-03       Impact factor: 10.539
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Authors:  Julia Proff; Charlotte U Brey; Armin Ensser; Wolfgang Holter; Manfred Lehner
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3.  Detection of antibody-secreting cells specific for the cytomegalovirus and herpes simplex virus surface antigens.

Authors:  Mira Alt; Jessica Falk; Anna Maria Eis-Hübinger; Barbara Kropff; Christian Sinzger; Adalbert Krawczyk
Journal:  J Immunol Methods       Date:  2018-07-27       Impact factor: 2.303

Review 4.  Insight for Immunotherapy of HCMV Infection.

Authors:  Xinmiao Long; Yi Qiu; Zuping Zhang; Minghua Wu
Journal:  Int J Biol Sci       Date:  2021-07-13       Impact factor: 6.580
  4 in total

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