Literature DB >> 11602761

Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein.

B N Lilley1, H L Ploegh, R S Tirabassi.   

Abstract

Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.

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Year:  2001        PMID: 11602761      PMCID: PMC114701          DOI: 10.1128/JVI.75.22.11218-11221.2001

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  27 in total

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Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

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Journal:  Intervirology       Date:  1978       Impact factor: 1.763

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Journal:  J Clin Microbiol       Date:  1975-10       Impact factor: 5.948

6.  An IgG-Fc receptor induced in cytomegalovirus-infected human fibroblasts.

Authors:  R Keller; R Peitchel; J N Goldman; M Goldman
Journal:  J Immunol       Date:  1976-03       Impact factor: 5.422

7.  Binding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus.

Authors:  Annika Antonsson; P J Hugo Johansson
Journal:  J Gen Virol       Date:  2001-05       Impact factor: 3.891

8.  Identification of a novel herpes simplex virus type 1-induced glycoprotein which complexes with gE and binds immunoglobulin.

Authors:  D C Johnson; V Feenstra
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103

9.  Fc receptor(s) induced by human cytomegalovirus bind differentially with human immunoglobulin G subclasses.

Authors:  T Murayama; S Natsuume-Sakai; K Shimokawa; T Furukawa
Journal:  J Gen Virol       Date:  1986-07       Impact factor: 3.891

10.  Human cytomegalovirus induces an Fc gamma receptor (Fc gammaR) in endothelial cells and fibroblasts that is distinct from the human cellular Fc gammaRs.

Authors:  L P MacCormac; J E Grundy
Journal:  J Infect Dis       Date:  1996-12       Impact factor: 5.226

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7.  The human cytomegalovirus-specific UL1 gene encodes a late-phase glycoprotein incorporated in the virion envelope.

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8.  Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs.

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