Literature DB >> 2673800

Effect of endothelin as a coronary vasoconstrictor in the Langendorff-perfused rat heart.

K Fukuda1, S Hori, M Kusuhara, T Satoh, S Kyotani, S Handa, Y Nakamura, H Oono, K Yamaguchi.   

Abstract

The effects of endothelin on coronary circulation were studied in isolated rat heart using a constant-flow system. Endothelin (10 fmol to 20 pmol/g heart weight) elevated the coronary perfusion pressure in a dose-dependent manner. Nifedipine (100 nM) inhibited the vasoconstriction and shifted the dose-response curve to the right. These results indicate that endothelin is a potent coronary vasoconstrictor and that its action is possibly mediated by the nifedipine-dependent Ca2+ channel.

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Year:  1989        PMID： 2673800     DOI： 10.1016/0014-2999(89)90725-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Effects of endothelin-1 on epicardial coronary tone, coronary blood flow, ECG-ST change and regional wall motion in anesthetized dogs.

Authors:  K Muramatsu; H Tomoike; Y Ohara; S Egashira; M Nakamura
Journal:  Heart Vessels       Date:  1991       Impact factor: 2.037

Review 2.  Endothelin and myocardial ischemia.

Authors:  D Hasdai; R Kornowski; A Battler
Journal:  Cardiovasc Drugs Ther       Date:  1994-08       Impact factor: 3.727

3.  Hemodynamic and inotropic effects of endothelin-1 in vivo.

Authors:  M E Beyer; S Nerz; B K Krämer; H M Hoffmeister
Journal:  Basic Res Cardiol       Date:  1994 Jan-Feb       Impact factor: 17.165

Review 4.  Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties.

Authors:  Walter E Knight; Hadi R Ali; Stephanie J Nakano; Cortney E Wilson; Lori A Walker; Kathleen C Woulfe
Journal:  Front Physiol       Date:  2021-01-08       Impact factor: 4.566
  4 in total

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