Literature DB >> 26733175

FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells.

Lei Cui1, Shengchun Dang1, Jianguo Qu1, Zhengfa Mao1, Xuqing Wang1, Jianxin Zhang1, Jixiang Chen2.   

Abstract

The transcriptional factor Forkhead box protein C2 (FOXC2) was recently demonstrated to be up-regulated in various cancer types. However, its expression profile and the biological functions in pancreatic cancer remain unknown. In this study, we examined the expression pattern of FOXC2 in pancreatic ductal adenocarcinoma (PDAC) tissues and investigated the functions of FOXC2 in the progression of PDAC. It was found that the expression of FOXC2 was up-regulated in PDAC samples. Forced expression of FOXC2 promoted the growth and migration of the PDAC cells, while knocking down the expression of FOXC2 inhibited the growth and migration of the PDAC cells. Moreover, FOXC2 was found to interact with beta-catenin and promote cell growth by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of FOXC2 in PDAC, and FOXC2 might be a therapeutic target for PDAC.

Entities:  

Keywords:  Beta-catenin/TCF signaling; Cell growth and migration; FOXC2; PDAC

Mesh：

Substances：

Year:  2016        PMID： 26733175     DOI： 10.1007/s13277-015-4607-4

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  24 in total

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