| Literature DB >> 26732130 |
Lingyu Zhang1, Yinyin Chen2, Zilu Li3, Lu Li4, Philippe Saint-Cricq3, Chunxia Li5, Jun Lin2, Chungang Wang6, Zhongmin Su1, Jeffrey I Zink3.
Abstract
A facile, reproducible, and scalable method was explored to construct uniform Au@poly(acrylic acid) (PAA) Janus nanoparticles (JNPs). The as-prepared JNPs were used as templates to preferentially grow a mesoporous silica (mSiO2 ) shell and Au branches separately modified with methoxy-poly(ethylene glycol)-thiol (PEG) to improve their stability, and lactobionic acid (LA) for tumor-specific targeting. The obtained octopus-type PEG-Au-PAA/mSiO2 -LA Janus NPs (PEG-OJNP-LA) possess pH and NIR dual-responsive release properties. Moreover, DOX-loaded PEG-OJNP-LA, upon 808 nm NIR light irradiation, exhibit obviously higher toxicity at the cellular and animal levels compared with chemotherapy or photothermal therapy alone, indicating the PEG-OJNP-LA could be utilized as a multifunctional nanoplatform for in vitro and in vivo actively-targeted and chemo-photothermal cancer therapy.Entities:
Keywords: active targeting; chemo-photothermal therapy; dual-stimuli responsive release; octopus-type Janus nanoparticles
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Year: 2016 PMID： 26732130 DOI： 10.1002/anie.201510409
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336