Literature DB >> 26732045

Pulmonary responses to pathogen-specific antigens in latent Mycobacterium tuberculosis infection.

Jessica R Jarvela1, Lori Tuscano1, Hung Lee1, Richard F Silver2.   

Abstract

In this study, we used ELISPOT to quantify frequencies of bronchoalveolar lavage (BAL) and peripheral blood T cells capable of producing IFNγ in response to PPD, antigen 85B, and Mtb-specific antigens CFP-10 and ESAT-6 in individuals with latent tuberculosis infection (LTBI) and Mtb-naïve controls. Compared to peripheral blood, BAL cells of LTBI subjects displayed significant enrichment for T cells responding to PPD, antigen 85B, and CFP-10, but not to ESAT-6. Baseline BAL cells of LTBI subjects displayed significant production of Mig (CXCL9) in response to PPD, antigen 85B, and CFP-10 as well. These findings suggest that enrichment for Mtb-specific T cells within BAL is not unique to active pulmonary tuberculosis and may, to the contrary, contribute to protection from re-infection in Mtb immune individuals. Published by Elsevier Ltd.

Entities:  

Keywords:  Bronchoalveolar lavage; ELISPOT; Immunodiagnosis; Latent tuberculosis infection; Tuberculosis

Mesh：

Substances：

Year:  2015        PMID： 26732045      PMCID： PMC6726121          DOI： 10.1016/j.tube.2015.10.006

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  17 in total

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Authors:  L A van Pinxteren; P Ravn; E M Agger; J Pollock; P Andersen
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2.  Resident Th1-like effector memory cells in pulmonary recall responses to Mycobacterium tuberculosis.

Authors:  Jessica Walrath; Lynn Zukowski; Adriana Krywiak; Richard F Silver
Journal:  Am J Respir Cell Mol Biol       Date:  2005-03-18       Impact factor: 6.914

3.  Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.

Authors:  Eliane M S Leyten; May Young Lin; Kees L M C Franken; Annemieke H Friggen; Corine Prins; Krista E van Meijgaarden; Martin I Voskuil; Karin Weldingh; Peter Andersen; Gary K Schoolnik; Sandra M Arend; Tom H M Ottenhoff; Michèl R Klein
Journal:  Microbes Infect       Date:  2006-06-13       Impact factor: 2.700

4.  Comparative genomics of BCG vaccines by whole-genome DNA microarray.

Authors:  M A Behr; M A Wilson; W P Gill; H Salamon; G K Schoolnik; S Rane; P M Small
Journal:  Science       Date:  1999-05-28       Impact factor: 47.728

5.  Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study.

Authors:  Claudia Jafari; Steven Thijsen; Giovanni Sotgiu; Delia Goletti; José Antonio Domínguez Benítez; Monica Losi; Ralf Eberhardt; Detlef Kirsten; Barbara Kalsdorf; Aik Bossink; Irene Latorre; Giovanni B Migliori; Alan Strassburg; Susanne Winteroll; Ulf Greinert; Luca Richeldi; Martin Ernst; Christoph Lange
Journal:  Am J Respir Crit Care Med       Date:  2009-07-09       Impact factor: 21.405

6.  Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis.

Authors:  K Dheda; R N van Zyl-Smit; R Meldau; S Meldau; G Symons; H Khalfey; N Govender; V Rosu; L A Sechi; A Maredza; P Semple; A Whitelaw; H Wainwright; M Badri; R Dawson; E D Bateman; A Zumla
Journal:  Thorax       Date:  2009-07-09       Impact factor: 9.139

7.  Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot.

Authors:  C Jafari; M Ernst; A Strassburg; U Greinert; B Kalsdorf; D Kirsten; C Lange
Journal:  Eur Respir J       Date:  2007-11-07       Impact factor: 16.671

8.  Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex.

Authors:  Claus Aagaard; Inger Brock; Anja Olsen; Tom H M Ottenhoff; Karin Weldingh; Peter Andersen
Journal:  J Infect Dis       Date:  2004-02-13       Impact factor: 5.226

9.  Recruitment of antigen-specific Th1-like responses to the human lung following bronchoscopic segmental challenge with purified protein derivative of Mycobacterium tuberculosis.

Authors:  Richard F Silver; Lynn Zukowski; Susan Kotake; Qing Li; Fatima Pozuelo; Adriana Krywiak; Rhonda Larkin
Journal:  Am J Respir Cell Mol Biol       Date:  2003-07       Impact factor: 6.914

10.  Rapid diagnosis of smear-negative tuberculosis using immunology and microbiology with induced sputum in HIV-infected and uninfected individuals.

Authors:  Ronan A M Breen; Gareth A D Hardy; Felicity M R Perrin; Sara Lear; Sabine Kinloch; Colette J Smith; Ian Cropley; George Janossy; Marc C I Lipman
Journal:  PLoS One       Date:  2007-12-19       Impact factor: 3.240
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  1 in total

1.  Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment.

Authors:  Uma Shanmugasundaram; Allison N Bucsan; Shashank R Ganatra; Chris Ibegbu; Melanie Quezada; Robert V Blair; Xavier Alvarez; Vijayakumar Velu; Deepak Kaushal; Jyothi Rengarajan
Journal:  JCI Insight       Date:  2020-07-23
  1 in total

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