Literature DB >> 26730885

Developing New Immunosuppression for the Next Generation of Transplant Recipients: The Path Forward.

M D Stegall1, R E Morris2, R R Alloway3, R B Mannon4.   

Abstract

The development of new immunosuppressive drugs has slowed markedly over the past several years, and the outlook that improved therapy will be available to the next generation of transplant recipients is bleak. In this viewpoint, the authors outline some of important barriers to new drug development and suggest specific steps that the transplant community can take to overcome them. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Entities:  

Keywords:  editorial/personal viewpoint; ethics and public policy Discipline

Mesh：

Substances：

Year:  2016        PMID： 26730885     DOI： 10.1111/ajt.13582

Source DB:  PubMed          Journal:  Am J Transplant        ISSN： 1600-6135            Impact factor:   8.086


  15 in total

1.  Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.

Authors:  Roslyn B Mannon; Brian Armstrong; Peter G Stock; Aneesh K Mehta; Alton B Farris; Natasha Watson; Yvonne Morrison; Minnie Sarwal; Tara Sigdel; Nancy Bridges; Mark Robien; Kenneth A Newell; Christian P Larsen
Journal:  Am J Transplant       Date:  2020-07-13       Impact factor: 8.086

2.  Surrogate Endpoints for Late Kidney Transplantation Failure.

Authors:  Maarten Naesens; Klemens Budde; Luuk Hilbrands; Rainer Oberbauer; Maria Irene Bellini; Denis Glotz; Josep Grinyó; Uwe Heemann; Ina Jochmans; Liset Pengel; Marlies Reinders; Stefan Schneeberger; Alexandre Loupy
Journal:  Transpl Int       Date:  2022-05-20       Impact factor: 3.842

3.  Demonstrating Benefit-Risk Profiles of Novel Therapeutic Strategies in Kidney Transplantation: Opportunities and Challenges of Real-World Evidence.

Authors:  Ilkka Helanterä; Jon Snyder; Anders Åsberg; Josep Maria Cruzado; Samira Bell; Christophe Legendre; Hélio Tedesco-Silva; Giovanna Tedesco Barcelos; Yvonne Geissbühler; Luis Prieto; Jennifer B Christian; Erik Scalfaro; Nancy A Dreyer
Journal:  Transpl Int       Date:  2022-05-03       Impact factor: 3.842

Review 4.  Biomarkers in Solid Organ Transplantation.

Authors:  John Choi; Albana Bano; Jamil Azzi
Journal:  Clin Lab Med       Date:  2018-12-17       Impact factor: 1.935

5.  An age-independent gene signature for monitoring acute rejection in kidney transplantation.

Authors:  Brian I Shaw; Daniel K Cheng; Chaitanya R Acharya; Robert B Ettenger; Herbert Kim Lyerly; Qing Cheng; Allan D Kirk; Eileen T Chambers
Journal:  Theranostics       Date:  2020-05-25       Impact factor: 11.556

6.  HLA-DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity.

Authors:  Chris Wiebe; Vasilis Kosmoliaptsis; Denise Pochinco; Ian W Gibson; Julie Ho; Patricia E Birk; Aviva Goldberg; Martin Karpinski; Jamie Shaw; David N Rush; Peter W Nickerson
Journal:  Am J Transplant       Date:  2018-12-15       Impact factor: 8.086

7.  The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.

Authors:  M Haas; A Loupy; C Lefaucheur; C Roufosse; D Glotz; D Seron; B J Nankivell; P F Halloran; R B Colvin; Enver Akalin; N Alachkar; S Bagnasco; Y Bouatou; J U Becker; L D Cornell; J P Duong van Huyen; I W Gibson; Edward S Kraus; R B Mannon; M Naesens; V Nickeleit; P Nickerson; D L Segev; H K Singh; M Stegall; P Randhawa; L Racusen; K Solez; M Mengel
Journal:  Am J Transplant       Date:  2018-01-21       Impact factor: 8.086

8.  Early Post-Transplant Torquetenovirus Viremia Predicts Cytomegalovirus Reactivations In Solid Organ Transplant Recipients.

Authors:  Fabrizio Maggi; Daniele Focosi; Maura Statzu; Gabriele Bianco; Cristina Costa; Lisa Macera; Pietro Giorgio Spezia; Chiara Medici; Eliseo Albert; David Navarro; Carolina Scagnolari; Mauro Pistello; Rossana Cavallo; Guido Antonelli
Journal:  Sci Rep       Date:  2018-10-19       Impact factor: 4.379

9.  Patient experience after kidney transplant: a conceptual framework of treatment burden.

Authors:  Elizabeth C Lorenz; Jason S Egginton; Mark D Stegall; Andrea L Cheville; Raymond L Heilman; Sumi Sukumaran Nair; Martin L Mai; David T Eton
Journal:  J Patient Rep Outcomes       Date:  2019-01-30

10.  Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics.

Authors:  Kylie Su Mei Yong; Zhisheng Her; Sue Yee Tan; Wilson Wei Sheng Tan; Min Liu; Fritz Lai; Shi Min Heng; Yong Fan; Kenneth Tou En Chang; Cheng-I Wang; Jerry Kok Yen Chan; Jianzhu Chen; Qingfeng Chen
Journal:  Front Immunol       Date:  2020-10-15       Impact factor: 7.561
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